Gotu Kola para Age-Related Cognitive Decline

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

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Conclusión

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

Key Study Findings

Systematic Review

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.

Dose: None vs: None Outcome: Cholinesterase inhibition and cognitive improvement Efecto: None None

Población: In vivo animal models of AD

Controlled Clinical Trial

Centella asiatica improves sleep quality and quantity in aged mice.

Dose: 1000 mg/kg/day vs: Control chow Outcome: Sleep quality and quantity (EEG/EMG) Efecto: None None

Población: 18-month-old male and female C57BL6/J mice

In Vitro

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and …

Dose: None vs: H2O2-induced oxidative stress Outcome: Neuroprotection and cognitive decline biomarkers Efecto: BDNF ~2.3-fold, NGF ~1.9-fold vs H2O2 None

Población: 3D intestinal model and neuronal/astrocytic co-culture

Other

Centella asiatica improves sleep quality and quantity in aged mice.

Dose: 1000 mg/kg/day vs: Control chow Outcome: Sleep composition (REM/NREM duration, arousals) Efecto: None None

Población: Aged (18-month) C57BL6/J mice

Review

Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments.

Dose: None vs: None Outcome: DM and AD symptom management Efecto: None None

Población: Patients with diabetes and Alzheimer's disease (review)

Other

Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.

Dose: None vs: None Outcome: AChE and BACE1 inhibition for Alzheimer's Efecto: None None

Población: In silico AD drug discovery (820 metabolites screened)

Key Statistics

Estudios

200

Participantes

↑

Positive

Calificación

Referenced Papers

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review. Review

Brain sciences 2025 14 citas

Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments. Review

Journal of ethnopharmacology 2025 6 citas

Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants. Other

PloS one 2025 3 citas

In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide. Other

Foods (Basel, Switzerland) 2025 3 citas

Bioactive potential of Centella asiatica leaf extract in acetylcholinesterase (AChE) inhibition: Insights from multiple ligand mapping. Other

Computers in biology … 2025 2 citas

Centella asiatica improves sleep quality and quantity in aged mice. Other

bioRxiv : the … 2025 1 citas

Centella asiatica improves sleep quality and quantity in aged mice. Other

Sleep advances : … 2025

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of … Other

Frontiers in aging 2024 11 citas

Centella asiatica improves memory and executive function in middle-aged rats by controlling oxidative stress and cholinergic transmission. Other

Journal of ethnopharmacology 2024 4 citas

A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation. Other

Food science & … 2024 3 citas

Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden. Other

Journal of Alzheimer's … 2024 3 citas

Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice. Other

Journal of Alzheimer's … 2024 2 citas

Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of … Other

bioRxiv : the … 2024

Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer's disease. Review

Tzu chi medical … 2023 6 citas

The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment. Other

Journal of pharmacological … 2022 18 citas

Neuroprotective Herbs for the Management of Alzheimer's Disease. Review

Biomolecules 2021 161 citas

Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica … Other

Neurobiology of aging 2021 29 citas

Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges. Other

Frontiers in nutrition 2021 13 citas

Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice. Other

Nutrients 2020 55 citas

Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions. Other

Drug metabolism and … 2020

Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. Review

CNS drugs 2013 138 citas

Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Other

Phytotherapy research : … 2007 256 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 500-1,000 mg/day standardized extract
cognitivesupport:: 750 mg/day

Límite superior: Not established; hepatotoxicity reported rarely at very high doses

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Positive	--
1000 mg/kg/day	--	Positive	--
None	--	Positive	--
1000 mg/kg/day	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
1 μg/mL	--	Positive	--

Mejor momento para tomar: With meals

Safety & Side Effects

Efectos secundarios reportados

⚠ Skin irritation (topical)
⚠ Headache
⚠ Gastrointestinal discomfort
⚠ Drowsiness
⚠ Rare: liver toxicity at very high doses

Interacciones conocidas

● Hepatotoxic drugs (additive liver stress)
● Sedative medications (additive CNS depression)
● Cholesterol-lowering drugs (theoretical interaction)

Ingesta máxima tolerable: Not established; hepatotoxicity reported rarely at very high doses

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Gotu Kola help with Age-Related Cognitive Decline?

Based on 4 studies with 200 participants, there is preliminary evidence that needs more research that Gotu Kola may support Age-Related Cognitive Decline management. Our evidence grade is D (Very Early Research).

How much Gotu Kola should I take for Age-Related Cognitive Decline?

Studies have used various dosages. A commonly studied range is 500-1,000 mg/day standardized extract. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Gotu Kola?

Reported side effects may include Skin irritation (topical), Headache, Gastrointestinal discomfort, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Gotu Kola and Age-Related Cognitive Decline?

We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Age-Related Cognitive Decline

Omega-3 Fatty Acids (DHA/EPA) A Phosphatidylserine B Bacopa monnieri B Vitamin B12 B Curcumin B Ginkgo biloba C

Veredicto rápido

A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.

Evidence Strength30%

Low confidence

Desglose de estudios

RCT (0)Meta (0)Other (4)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Age-Related Cognitive Decline

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.