Evidence-Based Supplement Reviews
Every brain claim cited.
We read the cognitive health studies so you don't have to.
Evidence-based supplement research you can trust. We analyze peer-reviewed clinical studies from PubMed and grade every supplement ingredient on a transparent A–D scale. No sponsored rankings, no manufacturer influence — just science.
Featured Ingredients
Acetyl-L-Carnitine
amino_acidFacilitates fatty acid transport into mitochondria for neuronal energy production; provides acetyl groups for acetylcholine synthesis; exhibits antioxidant properties protecting …
Alpha-GPC
choline_sourceProvides highly bioavailable choline that crosses the blood-brain barrier; serves as a precursor to acetylcholine, the primary neurotransmitter for learning …
Ashwagandha
herbAdaptogenic root that modulates the HPA axis to reduce cortisol levels; withanolides exhibit neuroprotective properties by reducing neuroinflammation, promoting GABA-mimetic …
Bacopa monnieri
herbEnhances synaptic communication by modulating serotonin, dopamine, and acetylcholine neurotransmitter systems; active bacosides promote antioxidant activity in the hippocampus and …
Citicoline
nootropicDonates choline for acetylcholine synthesis and cytidine for uridine production; supports phosphatidylcholine synthesis essential for neuronal membrane repair and integrity; …
Creatine
nootropicEnhances brain energy metabolism by replenishing ATP through the phosphocreatine system; supports mitochondrial function in neurons; may regulate neurotransmitter levels …
Top Conditions
Age-Related Cognitive Decline
Affects virtually all adults to some degree after age 50
Anxiety-Related Cognitive Impairment
Anxiety disorders affect 19% of US adults annually
Attention & Focus Difficulties
Among the most reported cognitive complaints across all age groups
Brain Fog
Reported by 20-30% of the general population
Depression-Related Cognitive Dysfunction
8.4% of US adults experience major depression; cognitive symptoms in 90%+ of episodes
Memory Loss
40% of adults over 65 experience some form of age-associated memory impairment
Recent Evidence Updates
10 studies
8 studies
12 studies
6 studies
10 studies
Popular Comparisons
Latest Research
J Sleep Res · 2017
European guideline for the diagnosis and treatment of insomnia.
Pflugers Arch · 2010
Glutamate receptors, neurotoxicity and neurodegeneration.
Pharmacol Res · 1999
Health benefits of docosahexaenoic acid (DHA).
Cell Mol Life Sci · 2005
Surface exposure of phosphatidylserine in pathological cells.
J Neurosci · 2000
Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen.
Circulation · 2010
OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction.
Guides & Resources
Exercise and Brain Health: How Physical Activity Supports Cognitive Function
Physical exercise is one of the most robustly supported interventions for brain health, with evidence spanning epidemiological studies, randomized controlled trials, and mechanistic neuroscience research. …
lifestyleSleep and Cognitive Performance: Why Rest Is Your Brain's Best Nootropic
Sleep is arguably the single most important factor in cognitive performance, yet it remains the most frequently sacrificed in pursuit of productivity. During sleep, the …
safetyCaffeine and L-Theanine: Synergy, Dosing, and Important Cautions
The combination of caffeine and L-theanine is often cited as the most well-studied nootropic stack, and for good reason. Multiple randomized controlled trials have demonstrated …
Evidence Grading System
Every supplement claim on this site is graded on an A–D scale based on peer-reviewed clinical research from PubMed. Our algorithm evaluates study design (RCTs rank highest), consistency of results, sample sizes, and the overall body of evidence. No manufacturer sponsorship influences our grades.
Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.
At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.
Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.
In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.
How It Works
No ads. No sponsored rankings. Just science.
Search PubMed
We search PubMed for every clinical study on supplement ingredients.
Extract Findings
We extract the key findings — sample sizes, study types, and results.
Grade A through F
We grade the evidence like a school report card — from A (strong) to F (negative).
Clear Answer
You get a clear answer in seconds — does this supplement actually work?
Cited Health Network
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FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.