What is the recommended dosage for Magnesium L-Threonate?

General: 1,500-2,000 mg/day (providing ~144 mg elemental magnesium); Cognitive Support: 2,000 mg/day

What are the side effects of Magnesium L-Threonate?

Potential side effects include: Drowsiness, Headache, Gastrointestinal discomfort, Mild diarrhea.

What is Magnesium L-Threonate?

Magnesium L-threonate (MgT) is a form of magnesium specifically developed by MIT researchers to cross the blood-brain barrier more effectively than other magnesium forms. It has been studied for its potential to increase brain magnesium levels and support synaptic plasticity and memory.

What dosage of Magnesium L-Threonate has been used in studies?

Clinical trials have used approximately 1,500 mg to 2,000 mg of magnesium L-threonate daily, providing roughly 144 mg of elemental magnesium. This is typically taken in divided doses. Consult your healthcare provider for appropriate dosing based on your magnesium status.

What are the potential side effects of Magnesium L-Threonate?

Side effects are generally mild and may include headache, drowsiness, and digestive discomfort. Excessive magnesium from any source may cause diarrhea. People with kidney disease should be cautious with magnesium supplements. Consult your healthcare provider before use.

Magnesium L-Threonate

mineral

Also known as: Magtein, MgT, Magnesium Threonate

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About

Magnesium L-Threonate is the only magnesium form demonstrated to effectively cross the blood-brain barrier. It increases synaptic density in hippocampal and prefrontal regions, enhancing both short-term and long-term memory. A 30-day RCT showed significant improvements across all five subcategories of clinical memory testing.

How It Works

The only magnesium form demonstrated to effectively cross the blood-brain barrier; increases synaptic density in hippocampal and prefrontal regions; enhances both short-term and long-term memory via NMDA receptor modulation and synaptic plasticity.

Evidence For Conditions

Condition	Grade	Studies	Participants
Memory Loss	B	6	450	View →
Sleep-Related Cognitive Impairment	C	4	300	View →

Side Effects

Drowsiness
Headache
Gastrointestinal discomfort
Mild diarrhea

Drug & Supplement Interactions

Antibiotics (quinolones, tetracyclines — reduced absorption)
Bisphosphonates (reduced absorption)
Diuretics (may affect magnesium levels)
Muscle relaxants (additive sedation)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Selenium Zinc

Quick Facts

Dosage: General: 1,500-2,000 mg/day (providing ~144 mg elemental magnesium); Cognitive_Support: 2,000 mg/day
Forms: capsule powder
Natural Sources: Not found naturally; synthesized from magnesium and L-threonic acid (vitamin C metabolite)
Upper Limit: 350 mg/day elemental magnesium from supplements (IOM)
Best Time: Evening preferred (may support sleep quality); split into 2-3 doses

Evidence Summary

Memory Loss B

Sleep-Related Cognitive Impairment C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.