Conditions

18 health conditions with evidence-based supplement research

Explore health conditions with evidence-graded supplement recommendations. Each condition page ranks ingredients by the strength of clinical research supporting them.

How We Grade Evidence

Each condition page ranks supplement ingredients by the strength of clinical evidence. Here is what each grade means:

Strong Evidence

Multiple randomized controlled trials (RCTs) or meta-analyses with consistent positive results and large sample sizes.

Good Evidence

At least one RCT with mostly consistent results across studies. Evidence suggests benefit but more research may be needed.

Some Evidence

Small studies or observational data with some positive signals. Promising but insufficient for strong recommendations.

Very Early Research

In vitro studies, case reports, or pilot studies only. Early-stage research that requires clinical validation.

Age-Related Cognitive Decline

Affects virtually all adults to some degree after age 50

Slower processing speed Difficulty with multitasking Word-finding difficulties +2

Anxiety-Related Cognitive Impairment

Anxiety disorders affect 19% of US adults annually

Racing thoughts Difficulty concentrating Impaired decision-making +2

Attention & Focus Difficulties

Among the most reported cognitive complaints across all age groups

Difficulty sustaining attention Easy distractibility Trouble completing tasks +2

Brain Fog

Reported by 20-30% of the general population

Difficulty concentrating Mental confusion Poor short-term memory +2

Cerebrovascular Health

Cerebrovascular risk factors present in 60%+ of adults over 60

Reduced mental sharpness Dizziness Difficulty with complex reasoning +1

Chemotherapy-Related Cognitive Impairment

Reported by 17-75% of cancer patients undergoing chemotherapy

Memory difficulties Trouble concentrating Difficulty multitasking +2

Depression-Related Cognitive Dysfunction

8.4% of US adults experience major depression; cognitive symptoms in 90%+ of episodes

Impaired concentration Indecisiveness Psychomotor retardation +2

Long COVID Cognitive Symptoms

Reported by 20-30% of COVID-19 survivors

Persistent brain fog Memory difficulties Impaired executive function +2

Memory Loss

40% of adults over 65 experience some form of age-associated memory impairment

Difficulty remembering recent events Frequently misplacing items Trouble recalling names +2

Mental Fatigue

Highly prevalent in modern knowledge-work environments

Difficulty concentrating for extended periods Increased error rates Reduced motivation +2

Mild Cognitive Impairment (MCI)

15-20% of adults over 65

Noticeable memory lapses Difficulty with complex reasoning Impaired judgment +2

Neurotransmitter Imbalance

Contributing factor in most cognitive and mood disorders

Mood instability Cognitive slowness Reduced motivation +2

Nutritional Deficiency Cognitive Impairment

40% of geriatric memory patients deficient in at least one brain-related vitamin

Progressive cognitive decline Memory impairment Fatigue and brain fog +2

Oxidative Stress & Neuroinflammation

Universal process that accelerates with age and environmental exposure

Accelerated cognitive aging Increased susceptibility to neurodegeneration Chronic low-grade brain inflammation +1

Perimenopause Cognitive Changes

Affects up to 60% of women during perimenopause (typically ages 45-55)

Verbal memory difficulties Difficulty concentrating Slower processing speed +2

Post-Concussion Cognitive Symptoms

1.6-3.8 million concussions/year in the US; 10-30% develop persistent symptoms

Persistent headache Difficulty concentrating Memory problems +2

Sleep-Related Cognitive Impairment

35% of adults sleep less than 7 hours; 50-70 million have sleep disorders

Daytime drowsiness Impaired memory consolidation Reduced reaction time +2

Stress-Induced Cognitive Decline

Chronic stress reported by 77% of US adults

Difficulty concentrating under pressure Memory retrieval problems Impaired decision-making +2

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.