What is the recommended dosage for Alpha-GPC?

General: 300-600 mg/day; Cognitive Support: 600-1,200 mg/day

What are the side effects of Alpha-GPC?

Potential side effects include: Headache, Insomnia, Dizziness, Gastrointestinal discomfort, Fishy body odor at high doses (TMAO conversion).

Alpha-GPC (alpha-glycerophosphocholine) is a choline-containing compound that serves as a precursor to the neurotransmitter acetylcholine. It is one of the most bioavailable forms of choline and has been studied for its potential role in supporting memory and cognitive function.

What dosage of Alpha-GPC has been used in studies?

Clinical studies have used doses ranging from 300 mg to 1,200 mg per day. A common dosage in cognitive research is 400 mg taken three times daily (1,200 mg total). Consult your healthcare provider for appropriate dosing.

What are the potential side effects of Alpha-GPC?

Alpha-GPC is generally well tolerated. Some people may experience headache, heartburn, insomnia, or dizziness. It may interact with anticholinergic medications. Consult your healthcare provider before taking Alpha-GPC, especially if you are on prescription medications.

Alpha-GPC

choline_source

Also known as: Alpha-Glycerylphosphorylcholine, L-Alpha Glycerylphosphorylcholine, Choline Alfoscerate

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About

Alpha-GPC is a highly bioavailable choline source that crosses the blood-brain barrier to serve as a precursor for acetylcholine, the primary neurotransmitter for learning and memory. Clinical studies in elderly patients show improvements in cognitive function scores, and it is used as a prescription drug in several European countries.

How It Works

Provides highly bioavailable choline that crosses the blood-brain barrier; serves as a precursor to acetylcholine, the primary neurotransmitter for learning and memory; promotes neural tissue health and enhances neuronal communication.

Evidence For Conditions

Condition	Grade	Studies	Participants
Neurotransmitter Imbalance	B	10	800	View →
Age-Related Cognitive Decline	C	8	600	View →

Side Effects

Headache
Insomnia
Dizziness
Gastrointestinal discomfort
Fishy body odor at high doses (TMAO conversion)

Drug & Supplement Interactions

Anticholinergic medications (opposes Alpha-GPC effects)
Cholinesterase inhibitors (additive cholinergic effects)
Scopolamine (opposes cholinergic effects)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Choline Bitartrate

Quick Facts

Dosage: General: 300-600 mg/day; Cognitive_Support: 600-1,200 mg/day
Forms: capsule powder liquid
Natural Sources: Trace amounts in dairy, organ meats, and soy, Concentrated form extracted from soy lecithin
Upper Limit: Not established; well-tolerated up to 1,200 mg/day
Best Time: Morning or split dose; with or without food

Evidence Summary

Neurotransmitter Imbalance B

Age-Related Cognitive Decline C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.