What is the recommended dosage for Ashwagandha?

General: 300-600 mg/day of root extract (KSM-66 or Sensoril); Cognitive Support: 600 mg/day

What are the side effects of Ashwagandha?

Potential side effects include: Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications).

Ashwagandha (Withania somnifera) is an adaptogenic herb used in traditional Ayurvedic medicine. Modern research has investigated its potential to support cognitive function, reduce stress-related cognitive impairment, and promote healthy cortisol levels.

What dosage of Ashwagandha has been used in cognitive studies?

Clinical trials for cognitive outcomes have typically used 300 mg to 600 mg daily of standardized root extract (such as KSM-66 or Sensoril). Some studies have used up to 1,000 mg per day. Consult your healthcare provider for personalized dosing.

What are the potential side effects of Ashwagandha?

Ashwagandha is generally well tolerated in clinical trials. Possible side effects include mild gastrointestinal discomfort, drowsiness, and headache. It may interact with thyroid, sedative, and immunosuppressant medications. Pregnant or nursing women should avoid use.

Ashwagandha

herb

Also known as: Withania somnifera, Indian Ginseng, Winter Cherry, KSM-66, Sensoril

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About

Ashwagandha is the most scientifically supported adaptogen for cognitive and stress-related outcomes. Its withanolides reduce neuroinflammation, promote GABA-mimetic activity, and support neuronal regeneration. In a double-blind RCT, 240 mg/day for 60 days significantly reduced anxiety, with moderate improvements in attention, executive function, and information processing speed.

How It Works

Adaptogenic root that modulates the HPA axis to reduce cortisol levels; withanolides exhibit neuroprotective properties by reducing neuroinflammation, promoting GABA-mimetic activity, and supporting neuronal regeneration.

Evidence For Conditions

Condition	Grade	Studies	Participants
Stress-Induced Cognitive Decline	B	14	1200	View →
Anxiety-Related Cognitive Impairment	B	12	1000	View →
Sleep-Related Cognitive Impairment	C	6	500	View →

Side Effects

Drowsiness
Gastrointestinal discomfort
Rare: liver injury (with contaminated or high-dose products)
Thyroid hormone elevation (may affect thyroid medications)

Drug & Supplement Interactions

Thyroid medications (may increase thyroid hormone levels)
Sedative medications (additive CNS depression)
Immunosuppressants (may stimulate immune activity)
Diabetes medications (may lower blood sugar)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Bacopa monnieri Ginkgo biloba Gotu Kola Panax Ginseng Rhodiola rosea

Quick Facts

Dosage: General: 300-600 mg/day of root extract (KSM-66 or Sensoril); Cognitive_Support: 600 mg/day
Forms: capsule powder liquid extract gummy
Natural Sources: Withania somnifera root
Upper Limit: Not established; well-tolerated up to 1,250 mg/day
Best Time: With meals; morning or evening depending on individual response

Evidence Summary

Stress-Induced Cognitive Decline B

Anxiety-Related Cognitive Impairment B

Sleep-Related Cognitive Impairment C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.