What is the recommended dosage for Rhodiola rosea?

General: 200-600 mg/day standardized to 3% rosavins and 1% salidroside

What are the side effects of Rhodiola rosea?

Potential side effects include: Insomnia or overstimulation (if taken late), Dry mouth, Dizziness, Mild agitation.

What is Rhodiola Rosea?

Rhodiola rosea is an adaptogenic herb native to arctic regions of Europe and Asia. Its active compounds, rosavins and salidroside, have been studied for their potential to reduce mental fatigue, support attention and cognitive function under stress, and promote resilience to physical and mental exhaustion.

What dosage of Rhodiola Rosea has been used in cognitive studies?

Clinical trials have commonly used 200 mg to 600 mg daily of standardized extract (typically 3% rosavins and 1% salidroside, such as SHR-5). Lower doses are generally used for daily mental performance, while higher doses have been studied for fatigue. Consult your healthcare provider.

What are the potential side effects of Rhodiola Rosea?

Rhodiola is generally well tolerated. Possible side effects include dizziness, dry mouth, and agitation, particularly at higher doses. It may interact with stimulant medications, antidepressants, and blood pressure drugs. It is best taken in the morning to avoid sleep disruption. Consult your doctor.

Rhodiola rosea

herb

Also known as: Golden Root, Arctic Root, Roseroot, Rhodiola

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About

Rhodiola rosea is an adaptogenic herb that modulates cortisol and stress-response pathways. Its active compounds rosavin and salidroside enhance monoamine neurotransmitter activity and support cognitive performance under stress and fatigue conditions. Multiple RCTs demonstrate significant reduction in mental fatigue.

How It Works

Adaptogenic herb that modulates cortisol and stress-response pathways via the HPA axis; active compounds rosavin and salidroside enhance monoamine neurotransmitter activity (serotonin, dopamine, norepinephrine); supports cognitive performance under stress.

Evidence For Conditions

Condition	Grade	Studies	Participants
Mental Fatigue	B	11	900	View →
Stress-Induced Cognitive Decline	B	8	600	View →

Side Effects

Insomnia or overstimulation (if taken late)
Dry mouth
Dizziness
Mild agitation

Drug & Supplement Interactions

Antidepressants (SSRIs, MAOIs — additive serotonergic effects)
Antidiabetic drugs (may lower blood sugar)
Stimulant medications (additive stimulatory effects)
Immunosuppressants (may modulate immune response)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Ashwagandha Bacopa monnieri Ginkgo biloba Gotu Kola Panax Ginseng

Quick Facts

Dosage: General: 200-600 mg/day standardized to 3% rosavins and 1% salidroside
Forms: capsule tablet liquid extract
Natural Sources: Rhodiola rosea plant (Arctic and mountainous regions of Europe and Asia)
Upper Limit: Not established; doses up to 680 mg/day used in trials
Best Time: Morning on empty stomach; avoid evening (may be stimulating)

Evidence Summary

Mental Fatigue B

Stress-Induced Cognitive Decline B

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.