Ginkgo biloba
herbAlso known as: Maidenhair Tree, EGb 761, Ginkgo Extract
About
Ginkgo biloba is the most extensively studied herbal supplement for cognitive function. Its flavonoid glycosides and terpene lactones enhance cerebral blood flow, provide antioxidant neuroprotection, and may modulate neurotransmitter systems. While the large GEM trial found no dementia prevention benefit, the standardized EGb 761 extract shows modest benefits for existing cognitive impairment.
How It Works
Enhances cerebral blood flow through vasodilation and blood viscosity reduction; flavonoid glycosides and terpene lactones provide antioxidant neuroprotection; may modulate acetylcholine and serotonin neurotransmitter systems.
Evidence For Conditions
| Condition | Grade | Studies | Participants | |
|---|---|---|---|---|
| Cerebrovascular Health | B | 12 | 2000 | View → |
| Age-Related Cognitive Decline | C | 40 | 8000 | View → |
Side Effects
- Headache
- Gastrointestinal upset
- Dizziness
- Allergic skin reactions (rare)
- Increased bleeding risk
Drug & Supplement Interactions
- Anticoagulants and antiplatelet drugs (increased bleeding risk)
- Anticonvulsants (may reduce seizure threshold)
- SSRIs (serotonin syndrome risk, rare)
- CYP3A4 substrates (may affect drug metabolism)
Always inform your healthcare provider about all supplements you take.
Related Ingredients
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.