What is the recommended dosage for Ashwagandha?

General: 300-600 mg/day of root extract (KSM-66 or Sensoril); Cognitive Support: 600 mg/day

What are the side effects of Ashwagandha?

Potential side effects include: Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications).

Ashwagandha (Withania somnifera) is an adaptogenic herb used in traditional Ayurvedic medicine. Modern research has investigated its potential to support cognitive function, reduce stress-related cognitive impairment, and promote healthy cortisol levels.

What dosage of Ashwagandha has been used in cognitive studies?

Clinical trials for cognitive outcomes have typically used 300 mg to 600 mg daily of standardized root extract (such as KSM-66 or Sensoril). Some studies have used up to 1,000 mg per day. Consult your healthcare provider for personalized dosing.

What are the potential side effects of Ashwagandha?

Ashwagandha is generally well tolerated in clinical trials. Possible side effects include mild gastrointestinal discomfort, drowsiness, and headache. It may interact with thyroid, sedative, and immunosuppressant medications. Pregnant or nursing women should avoid use.

Ashwagandha
Ashwagandha

herb

別名: Withania somnifera, Indian Ginseng, Winter Cherry, KSM-66, Sensoril

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About

Ashwagandha is the most scientifically supported adaptogen for cognitive and stress-related outcomes. Its withanolides reduce neuroinflammation, promote GABA-mimetic activity, and support neuronal regeneration. In a double-blind RCT, 240 mg/day for 60 days significantly reduced anxiety, with moderate improvements in attention, executive function, and information processing speed.

How It Works

Adaptogenic root that modulates the HPA axis to reduce cortisol levels; withanolides exhibit neuroprotective properties by reducing neuroinflammation, promoting GABA-mimetic activity, and supporting neuronal regeneration.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Stress-Induced Cognitive Decline	B	14	1200	詳細を見る →
Anxiety-Related Cognitive Impairment	B	12	1000	詳細を見る →
Sleep-Related Cognitive Impairment	C	6	500	詳細を見る →

Side Effects

Drowsiness
Gastrointestinal discomfort
Rare: liver injury (with contaminated or high-dose products)
Thyroid hormone elevation (may affect thyroid medications)

Drug & Supplement Interactions

Thyroid medications (may increase thyroid hormone levels)
Sedative medications (additive CNS depression)
Immunosuppressants (may stimulate immune activity)
Diabetes medications (may lower blood sugar)

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Rhodiola rosea Panax Ginseng Ginkgo biloba Bacopa monnieri Gotu Kola

基本情報

用量: General: 300-600 mg/day of root extract (KSM-66 or Sensoril); Cognitive_Support: 600 mg/day
剤形: capsule powder liquid extract gummy
天然の供給源: Withania somnifera root
上限量: Not established; well-tolerated up to 1,250 mg/day
推奨摂取タイミング: With meals; morning or evening depending on individual response

エビデンスの要約

Stress-Induced Cognitive Decline B

Anxiety-Related Cognitive Impairment B

Sleep-Related Cognitive Impairment C

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