Ashwagandha for Anxiety-Related Cognitive Impairment

Q: Does Ashwagandha help with Anxiety-Related Cognitive Impairment?

Based on 12 studies with 1,000 participants, there is moderate evidence from clinical studies that Ashwagandha may support Anxiety-Related Cognitive Impairment management. Our evidence grade is B (Good Evidence).

Q: How much Ashwagandha should I take for Anxiety-Related Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Ashwagandha and Anxiety-Related Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.

B Good Evidence At least one randomized trial supports this, with mostly consistent results.

Research suggests ashwagandha's withanolides may help reduce cortisol, support GABA-mimetic activity, and improve attention and executive function in individuals experiencing anxiety-related cognitive impairment.

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The Bottom Line

Key Study Findings

Review

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …

Dose: None vs: None Outcome: None Effect: None None

Population: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo Effect: None None

animal_study

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …

Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) vs: Placebo Effect: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001); <0.0001

In Vitro

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …

Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model) vs: Placebo Effect: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker

Key Statistics

Studies

1000

Participants

↑

Positive

Grade

Referenced Papers

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. Review

Nutrients 2026

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 citations

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 citations

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 citations

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:: 300-600 mg/day of root extract (KSM-66 or Sensoril)
cognitivesupport:: 600 mg/day

Upper limit: Not established; well-tolerated up to 1,250 mg/day

Dosages Studied in Research

Dosage	Duration	Effect	N
None	--	Positive	--
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)	--	Positive	--
ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)	--	Positive	--

Best taken: With meals; morning or evening depending on individual response

Safety & Side Effects

Reported Side Effects

⚠ Drowsiness
⚠ Gastrointestinal discomfort
⚠ Rare: liver injury (with contaminated or high-dose products)
⚠ Thyroid hormone elevation (may affect thyroid medications)

Known Interactions

● Thyroid medications (may increase thyroid hormone levels)
● Sedative medications (additive CNS depression)
● Immunosuppressants (may stimulate immune activity)
● Diabetes medications (may lower blood sugar)

Tolerable upper intake: Not established; well-tolerated up to 1,250 mg/day

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Ashwagandha help with Anxiety-Related Cognitive Impairment?

Based on 12 studies with 1,000 participants, there is moderate evidence from clinical studies that Ashwagandha may support Anxiety-Related Cognitive Impairment management. Our evidence grade is B (Good Evidence).

How much Ashwagandha should I take for Anxiety-Related Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Ashwagandha and Anxiety-Related Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.

Other ingredients for Anxiety-Related Cognitive Impairment

L-Theanine C

Ashwagandha for other conditions

Stress-Induced Cognitive Decline B Sleep-Related Cognitive Impairment C

Quick Verdict

Evidence Strength72%

High confidence

Study Breakdown

RCT (0)Meta (0)Other (12)

Compare Alternatives

See how other ingredients compare for this condition.

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References

[1] Kaj Winther. Nutrients. 2026. The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. doi:10.3390/nu18050871 PubMed
[2] Hyeongyeong Kim et al.. J Ethnopharmacol. 2025. Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … doi:10.1016/j.jep.2024.119224 PubMed
[3] Sindgi Vasudeva Murthy et al.. Prev Nutr Food Sci. 2022. Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … doi:10.3746/pnf.2022.27.1.108 PubMed
[4] Heba M A Khalil et al.. J Ethnopharmacol. 2021. Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … doi:10.1016/j.jep.2021.114141 PubMed
[5] Nawab John Dar et al.. J Ethnopharmacol. 2020. Neurodegenerative diseases and Withania somnifera (L.): An update. doi:10.1016/j.jep.2020.112769 PubMed

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.