Ginkgo biloba ： Cerebrovascular Health

Research suggests Ginkgo may help enhance cerebral blood flow through vasodilation. More consistent benefits are observed for vascular-related cognitive symptoms than for general cognitive decline.

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結論

Research suggests Ginkgo may help enhance cerebral blood flow through vasodilation. More consistent benefits are observed for vascular-related cognitive symptoms than for general cognitive decline.

Key Study Findings

Review

[Treatment of mild cognitive impairment: value of citicoline].

Dose: None vs: None Outcome: cognitive function improvement in mild cognitive impairment 効果: None None

対象集団: elderly patients with mild cognitive impairment or chronic brain diseases

Review

Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines.

Dose: None vs: None Outcome: ASD symptom management 効果: None None

対象集団: Children with autism spectrum disorder

Other

Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 …

Dose: None vs: BCAS model mice without GBE50 Outcome: Cognitive impairment and white matter lesions 効果: None None

対象集団: BCAS cerebral small vessel disease mouse model

Meta-Analysis n=22347

Therapeutic strategies in vascular cognitive impairment: A systematic review and meta-analysis.

Dose: None vs: Various controls Outcome: Cognition and functional outcomes in VCI 効果: Ginkgo biloba: Cohen's d 0.83 [0.00-1.67] cognitio None

対象集団: Patients with vascular cognitive impairment (173 trials)

Other 10 weeks

Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of …

Dose: None vs: Untreated APP/PS1 mice Outcome: Cognitive performance in behavioral tests 効果: None None

対象集団: APP/PS1 transgenic Alzheimer's disease mouse model

In Vitro

Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 …

Dose: None vs: OGD/R model vs control in HT22 cells Outcome: Cell proliferation and migration via RhoA-ROCK2 効果: None None

対象集団: HT22 mouse hippocampal neurons under OGD/R

Key Statistics

研究数

2000

参加者数

↑

Positive

グレード

Referenced Papers

[Treatment of mild cognitive impairment: value of citicoline]. Review

Revista de neurologia None 3 件の引用

Identification of a central regulator of ginkgolide biosynthesis in Ginkgo biloba that integrates jasmonate and light signaling. Other

Proceedings of the … 2025 8 件の引用

Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease. Other

Phytomedicine : international … 2025 6 件の引用

Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment. Other

Journal of ethnopharmacology 2025 5 件の引用

Yindan Xinnaotong Soft Capsule improves post-ischemic stroke recovery by regulating CREB/BDNF-mediated synaptic plasticity and CREB/VEGFA-mediated angiogenesis. Other

Phytomedicine : international … 2025 4 件の引用

Therapeutic strategies in vascular cognitive impairment: A systematic review and meta-analysis. Meta-Analysis

Alzheimer's & dementia … 2025 4 件の引用

Traditional, complementary, and integrative medicine in the management of ischemic stroke: a narrative review. Review

Frontiers in pharmacology 2025 3 件の引用

Antithrombotic Effect of Ginkgo Biloba Extract: A Study Based on Network Pharmacological Analysis and In vivo Experiments. Other

Nigerian journal of … 2025 2 件の引用

Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway. Other

Metabolic brain disease 2025 1 件の引用

Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. Review

Alternative therapies in … 2025

Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. Review

Degenerative neurological and … 2024 66 件の引用

[Not Available]. Review

Acta pharmaceutica Sinica. … 2024 33 件の引用

Anti-oxidative and anti-inflammatory effects of Ginkgo biloba extract (EGb761) on hindlimb skeletal muscle ischemia-reperfusion injury in rats. Other

Physiological reports 2024 5 件の引用

Clinical efficacy and mechanism of Ginkgo biloba extract in the treatment of elderly ischemic cerebrovascular disease. RCT

Pakistan journal of … 2024 2 件の引用

Ginkgo biloba GbbZIP08 transcription factor is involved in the regulation of flavonoid biosynthesis. Other

Journal of plant … 2023 18 件の引用

Ginkgo biloba Extract Drives Gut Flora and Microbial Metabolism Variation in a Mouse Model of Alzheimer's Disease. Other

Pharmaceutics 2023 13 件の引用

Efficacy and safety of Ginkgo biloba dropping pills in the treatment of coronary heart disease with stable angina pectoris and … Other

BMJ open 2023 4 件の引用

Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a … Other

PloS one 2023

Leaves, seeds and exocarp of Ginkgo biloba L. (Ginkgoaceae): A Comprehensive Review of Traditional Uses, phytochemistry, pharmacology, resource utilization and … Review

Journal of ethnopharmacology 2022 97 件の引用

Traditional medicine in China for ischemic stroke: bioactive components, pharmacology, and mechanisms. Review

Journal of integrative … 2022 33 件の引用

Benefits of Treatment with Ginkgo Biloba Extract EGb 761 Alone or Combined with Acetylcholinesterase Inhibitors in Vascular Dementia. Other

Clinical drug investigation 2022 22 件の引用

Ginkgo biloba L. extract prevents steroid-induced necrosis of the femoral head by rescuing apoptosis and dysfunction in vascular endothelial cells … Other

Journal of ethnopharmacology 2022 17 件の引用

Biflavonoids from Ginkgo biloba leaves as a novel anti-atherosclerotic candidate: Inhibition potency and mechanistic analysis. Other

Phytomedicine : international … 2022 16 件の引用

Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a … Other

Gynecological endocrinology : … 2022 6 件の引用

Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a … Other

Gynecological endocrinology : … 2022 5 件の引用

[Expert consensus on clinical application of GBE50 Dispersible Tablets for ischemic cardiovascular and cerebrovascular diseases]. Other

Zhongguo Zhong yao … 2022 2 件の引用

Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke. Review

Frontiers in cellular … 2021 40 件の引用

Strategies for the use of Ginkgo biloba extract, EGb 761® , in the treatment and management of mild cognitive impairment … Other

CNS neuroscience & … 2021 38 件の引用

The Clinical Efficacy of Ginkgo biloba Leaf Preparation on Ischemic Stroke: A Systematic Review and Meta-Analysis. Review

Evidence-based complementary and … 2021 24 件の引用

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 件の引用

Isorhamnetin: A review of pharmacological effects. Review

Biomedicine & pharmacotherapy … 2020 427 件の引用

Efficacy and Safety of Ginkgo biloba in Patients with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis. Meta-Analysis

The American journal … 2020 24 件の引用

[Similarities and differences between Ginkgo biloba and Panax notoginseng in treatment of ischemic cerebrovascular disease]. Other

Zhongguo Zhong yao … 2020 3 件の引用

Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba … Review

CNS neuroscience & … 2019 116 件の引用

Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of … Meta-Analysis

International psychogeriatrics 2018 83 件の引用

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases. Review

Aging and disease 2017 96 件の引用

Systematic Investigation of Ginkgo Biloba Leaves for Treating Cardio-cerebrovascular Diseases in an Animal Model. Other

ACS chemical biology 2017 78 件の引用

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 件の引用

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine. Review

Evidence-based complementary and … 2016 19 件の引用

Effect of Ginkgo Biloba Extract on the Pharmacokinetics and Metabolism of Clopidogrel in Rats. Other

Phytotherapy research : … 2016 13 件の引用

Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders. Review

Integrative medicine insights 2015 100 件の引用

Ginkgo biloba Extract 761: A Review of Basic Studies and Potential Clinical Use in Psychiatric Disorders. Review

CNS & neurological … 2015 63 件の引用

Improved metabolites of pharmaceutical ingredient grade Ginkgo biloba and the correlated proteomics analysis. Other

Proteomics 2015 14 件の引用

Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract. Other

Sultan Qaboos University … 2012 27 件の引用

Normal cognitive decline or dementia? Other

The Practitioner 2010

Efficacy and tolerability of Ginkgo biloba extract EGb 761 by type of dementia: analyses of a randomised controlled trial. RCT

Journal of the … 2009 87 件の引用

Ginkgo and Alzheimer's disease: little or no different from placebo. Other

Prescrire international 2007 2 件の引用

Ginkgo biloba normalises stress-elevated alterations in brain catecholamines, serotonin and plasma corticosterone levels. Other

European neuropsychopharmacology : … 2003 55 件の引用

Ginkgo biloba extract: review of CNS effects. Review

Annals of clinical … 2003 47 件の引用

Ginkgo biloba. Review

American family physician 2003

Pharmacologic treatments of dementia. Review

The Medical clinics … 2002 59 件の引用

Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Review

Alternative therapies in … 2001

Ginkgo biloba extract: mechanisms and clinical indications. Review

Archives of physical … 2000 408 件の引用

Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. Review

Life sciences 2000 41 件の引用

Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use. Case Report

The Journal of … 2000 39 件の引用

Nutrients, age and cognitive function. Review

Current opinion in … 1998 30 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones

上限量： 600 mg/day (doses above show no additional benefit)

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	22347
None	10 weeks	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--

推奨摂取タイミング： With meals; may require 4-6 weeks for full effects

Safety & Side Effects

報告されている副作用

⚠ Headache
⚠ Gastrointestinal upset
⚠ Dizziness
⚠ Allergic skin reactions (rare)
⚠ Increased bleeding risk

既知の相互作用

● Anticoagulants and antiplatelet drugs (increased bleeding risk)
● Anticonvulsants (may reduce seizure threshold)
● SSRIs (serotonin syndrome risk, rare)
● CYP3A4 substrates (may affect drug metabolism)

耐容上限摂取量： 600 mg/day (doses above show no additional benefit)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Ginkgo biloba help with Cerebrovascular Health?

Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Ginkgo biloba may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).

How much Ginkgo biloba should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 120-240 mg/day standardized to 24% flavone glycosides and 6% terpene lactones. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Ginkgo biloba?

Reported side effects may include Headache, Gastrointestinal upset, Dizziness, Allergic skin reactions (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Ginkgo biloba and Cerebrovascular Health?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Cerebrovascular Health

Omega-3 Fatty Acids (DHA/EPA) B Resveratrol C

Ginkgo biloba 他の症状・状態について

Age-Related Cognitive Decline C

総合評価

Research suggests Ginkgo may help enhance cerebral blood flow through vasodilation. More consistent benefits are observed for vascular-related cognitive symptoms than for general cognitive decline.

Evidence Strength72%

High confidence

研究の内訳

RCT (3)Meta (3)Other (6)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Cerebrovascular Health

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。