Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.

T Vogel, N Dali-Youcef, G Kaltenbach, E Andrès

Systematic Review International journal of clinical practice 2009 125 件の引用

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Study Design

研究タイプ: Systematic Review
対象集団: dementia patients

介入: Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. None
比較対照: None
主要アウトカム: cognitive function
効果の方向: Neutral
バイアスリスク: Low

Abstract

Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B(12) and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults.

要約

Current knowledge on the relationship between homocysteine, folate and vitamin B12 levels and the way their disruption influences cognitive function in adults is reviewed.

Used In Evidence Reviews

B Vitamin B12 ： Age-Related Cognitive Decline

Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.

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Study Design

Abstract

要約

Used In Evidence Reviews

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