Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.

T Vogel, N Dali-Youcef, G Kaltenbach, E Andrès

Systematic Review International journal of clinical practice 2009 125 인용

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Study Design

연구 유형: Systematic Review
대상 집단: dementia patients

중재: Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. None
대조군: None
일차 결과: cognitive function
효과 방향: Neutral
비뚤림 위험: Low

Abstract

Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B(12) and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults.

요약

Current knowledge on the relationship between homocysteine, folate and vitamin B12 levels and the way their disruption influences cognitive function in adults is reviewed.

Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.

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Study Design

Abstract

요약

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