Skip to main content
BrainCited

Folate cho Nutritional Deficiency Cognitive Impairment

B

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

<\/script>\n
`; }, get iframeSnippet() { const domain = 'braincited.com'; const params = 'ingredient\u003Dfolate\u0026condition\u003Dnutritional\u002Ddeficiency\u002Dcognitive'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    

Widget powered by . Free, no account required.

B

Kết luận

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

Key Study Findings

Observational Study n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None so với: None Outcome: Cognitive impairment risk Hiệu quả: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Đối tượng nghiên cứu: Elderly participants aged 60+ from NHANES 2011-2014

Cross-Sectional Study n=1966
Folate mediates cognitive impairment of aged people with periodontitis.
Dose: None so với: Placebo Hiệu quả: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1% None
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None so với: None Outcome: Pregnancy outcomes and offspring neurodevelopment Hiệu quả: None None

Đối tượng nghiên cứu: Pregnant women (review)

Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None so với: Standard care or placebo Outcome: Global cognition in stroke survivors Hiệu quả: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Đối tượng nghiên cứu: Adult stroke survivors (20 trials + 14 observational)

Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None so với: None Outcome: Causal association of micronutrients with RLS Hiệu quả: Retinol OR 0.46; Mg OR 0.62 None

Đối tượng nghiên cứu: European ancestry (7248 RLS cases, 19802 controls)

Randomized Controlled Trial Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented) so với: Within-trial comparison Outcome: B12/homocysteine association with PD outcomes Hiệu quả: None None

Đối tượng nghiên cứu: Early Parkinson's disease patients

Key Statistics

10

Nghiên cứu

1500

Người tham gia

Positive

B

Xếp hạng

Referenced Papers

Nutritional neuroscience 2025 1 trích dẫn
Food and nutrition … 2024 19 trích dẫn
Nutrition and health 2021 13 trích dẫn
The Senior care … 2021 2 trích dẫn
Journal of Alzheimer's … 2018 281 trích dẫn
European journal of … 2012 225 trích dẫn
Evidence report/technology assessment 2006
The Cochrane database … 2003 263 trích dẫn
Current opinion in … 1998 30 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:
400 mcg DFE/day (RDA)
cognitivesupport:
400-800 mcg/day

Giới hạn trên: 1,000 mcg/day from supplements (may mask B12 deficiency)

Liều lượng đã nghiên cứu

Liều lượng Thời gian Hiệu quả N
None -- Positive 2582
None -- Positive 1966
None -- Positive --
None -- Mixed --
None -- Mixed --
Vitamin B12 (measured, not supplemented) -- Positive --
None -- Positive --
>5 mg/day -- Negative --

Thời điểm dùng tốt nhất: With or without food; morning preferred

Safety & Side Effects

Tác dụng phụ đã được báo cáo

  • Generally well-tolerated
  • May mask B12 deficiency symptoms
  • Rare: insomnia or irritability at high doses

Tương tác đã biết

  • Methotrexate (antagonist — folate reduces efficacy)
  • Anticonvulsants (phenytoin, carbamazepine — mutual interference)
  • Sulfasalazine (reduces folate absorption)

Mức hấp thụ tối đa cho phép: 1,000 mcg/day from supplements (may mask B12 deficiency)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Folate help with Nutritional Deficiency Cognitive Impairment?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Folate should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate?
Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Các thành phần khác cho Nutritional Deficiency Cognitive Impairment

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.