Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.

T Vogel, N Dali-Youcef, G Kaltenbach, E Andrès

Systematic Review International journal of clinical practice 2009 125 trích dẫn

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Study Design

Loại nghiên cứu: Systematic Review
Đối tượng nghiên cứu: dementia patients

Can thiệp: Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. None
Đối chứng: None
Kết quả chính: cognitive function
Xu hướng hiệu quả: Neutral
Nguy cơ sai lệch: Low

Abstract

Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B(12) and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults.

Tóm lược

Current knowledge on the relationship between homocysteine, folate and vitamin B12 levels and the way their disruption influences cognitive function in adults is reviewed.

Used In Evidence Reviews

B Vitamin B12 cho Age-Related Cognitive Decline

Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.

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Abstract

Tóm lược

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