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Figure 3. RACK1 and RACK2 levels in the hippocampus of young, middle-aged, and aged rats. Western Blot analysis of RACK1 (a) and RACK2 (b) expression in young (Y), middle aged (M) and old (O) rats hippocampus. RACK1 and RACK2 levels differed significantly b
Figure 11. Figure 3. RACK1 and RACK2 levels in the hippocampus of young, middle-aged, and aged rats. Western Blot analysis of RACK1 (a) and RACK2 (b) expression in young (Y), middle aged (M) and old (O) rats hippocampus. RACK1 and RACK2 levels differed significantly between the aged rat group and the other two age groups. No significant differences in RACK1 and RACK2 levels were found between young and middle-aged groups.* p < 0.02 compared to the middle-aged group, and * p < 0.05 compared to the young group for RACK1. * p < 0.02 compared to the young group; and * p < 0.05 compared to the middle-aged group for RACK2 (n = 4 for each group).

Beschreibung

RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions.

More Figures from This Paper

Subcellular distribution of PKC isoforms between cytosolic and membrane fractions is analyzed, showing altered translocation patterns in aged brain tissue.

Figure 5

Subcellular distribution of PKC isoforms between cytosolic and membrane fractions is analyzed, showing altered translocation patterns in aged brain tissue.

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RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms.

Figure 6

RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms.

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Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction.

Figure 7

Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction.

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Quantitative densitometry of PKC isoform bands confirms statistically significant declines in neuroprotective PKC levels with advancing age.

Figure 8

Quantitative densitometry of PKC isoform bands confirms statistically significant declines in neuroprotective PKC levels with advancing age.

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Activated PKC translocation to membrane fractions is diminished in aged rats, with reduced binding to RACK scaffolding proteins contributing to impaired neuroprotective signaling.

Figure 9

Activated PKC translocation to membrane fractions is diminished in aged rats, with reduced binding to RACK scaffolding proteins contributing to impaired neuroprotective signaling.

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Schematic representation of PKC isoform and RACK protein distribution in membrane fractions of young versus aged rat hippocampus illustrates the age-dependent loss of neuroprotective mechanisms.

Figure 10

Schematic representation of PKC isoform and RACK protein distribution in membrane fractions of young versus aged rat hippocampus illustrates the age-dependent loss of neuroprotective mechanisms.

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Figure 11

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Source Paper

Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection.

International journal of molecular sciences (2019)

PMID: 31331067

DOI: 10.3390/ijms20143544

Cite This Figure

![Figure 11: RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions.](https://pdfs.citedhealth.com/figures/31331067/133.png)

> Source: Donatella Pastore et al. "Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mech." *International journal of molecular sciences*, 2019. PMID: [31331067](https://pubmed.ncbi.nlm.nih.gov/31331067/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/31331067/133.png" alt="RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions." />
  <figcaption>Figure 11. RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions.<br>  Source: Donatella Pastore et al. "Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mech." <em>International journal of molecular sciences</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31331067/">31331067</a></figcaption>
</figure>

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