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Fig. 6 A schematic diagram illustrates these profiled CSF metabolites change during brain aging process. These aging‑related CSF metabolomic change might suggest possible blood‑brain barrier(BBB) breakdown, neuroinflammation, and mitochodrial dysfunction
Figure 10. Fig. 6 A schematic diagram illustrates these profiled CSF metabolites change during brain aging process. These aging‑related CSF metabolomic change might suggest possible blood‑brain barrier(BBB) breakdown, neuroinflammation, and mitochodrial dysfunction in aged brain circulation. Metabolites marked in blue refer to those which decreased in the elderly, while metabolites marked in red refer to those which increased with increasing age

Beschreibung

A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways.

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Scatter plots of individual metabolite abundance versus age reveal significant correlations for specific compounds, suggesting continuous metabolic drift across the lifespan.

Figure 6

Scatter plots of individual metabolite abundance versus age reveal significant correlations for specific compounds, suggesting continuous metabolic drift across the lifespan.

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Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns.

Figure 7

Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns.

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Pathway enrichment analysis of age-associated CSF metabolites identifies disrupted metabolic pathways, including amino acid and lipid metabolism, during brain aging.

Figure 8

Pathway enrichment analysis of age-associated CSF metabolites identifies disrupted metabolic pathways, including amino acid and lipid metabolism, during brain aging.

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Receiver operating characteristic curves evaluate the discriminative ability of selected CSF metabolites to distinguish older from younger cognitively healthy adults.

Figure 9

Receiver operating characteristic curves evaluate the discriminative ability of selected CSF metabolites to distinguish older from younger cognitively healthy adults.

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Figure 10

Diagram
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Source Paper

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry.

BMC geriatrics (2023)

PMID: 37020298

DOI: 10.1186/s12877-023-03939-6

Cite This Figure

![Figure 10: A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways.](https://pdfs.citedhealth.com/figures/37020298/181.png)

> Source: Fu-Chao Liu et al. "Exploring the aging process of cognitively healthy adults by analyzing cerebrosp." *BMC geriatrics*, 2023. PMID: [37020298](https://pubmed.ncbi.nlm.nih.gov/37020298/)
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  <img src="https://pdfs.citedhealth.com/figures/37020298/181.png" alt="A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways." />
  <figcaption>Figure 10. A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways.<br>  Source: Fu-Chao Liu et al. "Exploring the aging process of cognitively healthy adults by analyzing cerebrosp." <em>BMC geriatrics</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37020298/">37020298</a></figcaption>
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