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Curcumin exerts broad-spectrum anti-inflammatory effects predominantly via modulation of the nuclear factor kappa B (NF-κB) signaling pathway [70]. By inhibiting NF-κB activation, curcumin suppresses the transcription of pivotal pro-inflammatory mediators
Figure 2. Curcumin exerts broad-spectrum anti-inflammatory effects predominantly via modulation of the nuclear factor kappa B (NF-κB) signaling pathway [70]. By inhibiting NF-κB activation, curcumin suppresses the transcription of pivotal pro-inflammatory mediators, including cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), COX-2, and iNOS. This downregulation reduces the biosynthesis of nitric oxide (NO) and prostaglandins, culminating in attenuation of both systemic and central nervous system inflammation. Consequently, curcumin is regarded as a promising adjunct therapeutic agent in inflammatory and neurodegenerative disorders (Figure 2).

Beschreibung

Curcumin's anti-inflammatory mechanisms operate primarily through modulation of the NF-kappa-B signaling pathway. The diagram illustrates how curcumin suppresses neuroinflammatory cascades implicated in Alzheimer's disease, Parkinson's disease, and post-stroke cognitive impairment.

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Overview of curcumin's pharmacokinetic challenges following oral administration, including poor systemic bioavailability due to limited intestinal absorption and rapid hepatic metabolism. The narrative review discusses strategies to enhance curcumin delivery to the central nervous system for neuroprotective applications.

Figure 1

Overview of curcumin's pharmacokinetic challenges following oral administration, including poor systemic bioavailability due to limited intestinal absorption and rapid hepatic metabolism. The narrative review discusses strategies to enhance curcumin delivery to the central nervous system for neuroprotective applications.

diagram

Figure 2

Diagram
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Source Paper

The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation-A Narrative Review.

Nutrients (2025)

PMID: 40944272

DOI: 10.3390/nu17172884

Cite This Figure

![Figure 2: Curcumin's anti-inflammatory mechanisms operate primarily through modulation of the NF-kappa-B signaling pathway. The diagram illustrates how curcumin suppresses neuroinflammatory cascades implicated in Alzheimer's disease, Parkinson's disease, and post-stroke cognitive impairment.](https://pdfs.citedhealth.com/figures/40944272/226.png)

> Source: Andrea Lehoczki et al. "The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Transl." *Nutrients*, 2025. PMID: [40944272](https://pubmed.ncbi.nlm.nih.gov/40944272/)
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  <img src="https://pdfs.citedhealth.com/figures/40944272/226.png" alt="Curcumin's anti-inflammatory mechanisms operate primarily through modulation of the NF-kappa-B signaling pathway. The diagram illustrates how curcumin suppresses neuroinflammatory cascades implicated in Alzheimer's disease, Parkinson's disease, and post-stroke cognitive impairment." />
  <figcaption>Figure 2. Curcumin's anti-inflammatory mechanisms operate primarily through modulation of the NF-kappa-B signaling pathway. The diagram illustrates how curcumin suppresses neuroinflammatory cascades implicated in Alzheimer's disease, Parkinson's disease, and post-stroke cognitive impairment.<br>  Source: Andrea Lehoczki et al. "The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Transl." <em>Nutrients</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/40944272/">40944272</a></figcaption>
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Curcumin für Oxidative Stress & Neuroinflammation

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