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Fig. 3 Scatter plot of log2 transformed metabolite abundance and its correlation with age in metabolites with significant correlation with aging. Value refers to log2 transformed intensity and age is given in years. The colored zones refer to 95% confiden
Figure 7. Fig. 3 Scatter plot of log2 transformed metabolite abundance and its correlation with age in metabolites with significant correlation with aging. Value refers to log2 transformed intensity and age is given in years. The colored zones refer to 95% confidence intervals of the regressions

Descripción

Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns.

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Scatter plots of individual metabolite abundance versus age reveal significant correlations for specific compounds, suggesting continuous metabolic drift across the lifespan.

Figure 6

Scatter plots of individual metabolite abundance versus age reveal significant correlations for specific compounds, suggesting continuous metabolic drift across the lifespan.

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Pathway enrichment analysis of age-associated CSF metabolites identifies disrupted metabolic pathways, including amino acid and lipid metabolism, during brain aging.

Figure 8

Pathway enrichment analysis of age-associated CSF metabolites identifies disrupted metabolic pathways, including amino acid and lipid metabolism, during brain aging.

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Receiver operating characteristic curves evaluate the discriminative ability of selected CSF metabolites to distinguish older from younger cognitively healthy adults.

Figure 9

Receiver operating characteristic curves evaluate the discriminative ability of selected CSF metabolites to distinguish older from younger cognitively healthy adults.

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A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways.

Figure 10

A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways.

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Figure 7

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Source Paper

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry.

BMC geriatrics (2023)

PMID: 37020298

DOI: 10.1186/s12877-023-03939-6

Cite This Figure

![Figure 7: Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns.](https://pdfs.citedhealth.com/figures/37020298/135.png)

> Source: Fu-Chao Liu et al. "Exploring the aging process of cognitively healthy adults by analyzing cerebrosp." *BMC geriatrics*, 2023. PMID: [37020298](https://pubmed.ncbi.nlm.nih.gov/37020298/)
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  <img src="https://pdfs.citedhealth.com/figures/37020298/135.png" alt="Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns." />
  <figcaption>Figure 7. Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns.<br>  Source: Fu-Chao Liu et al. "Exploring the aging process of cognitively healthy adults by analyzing cerebrosp." <em>BMC geriatrics</em>, 2023. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/37020298/">37020298</a></figcaption>
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