Creatine pour Mental Fatigue

A systematic review found moderate certainty evidence for positive effects on memory and processing speed. Single-dose supplementation improved cognitive performance during sleep deprivation through ATP replenishment.

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En conclusion

Key Study Findings

Review

Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse?

Dose: None vs: None Outcome: None Effet: None None

Population: narrative review of creatine supplementation effects on brain function

Other 24 weeks

Analysis of Incidence and Clinical Characteristics of RSV Infection in Hospitalized Children: A Retrospective Study.

Dose: 71.9% vs: None Outcome: None Effet: None None

Population: rsv infection from january 2019 to december 2020

Randomized Controlled Trial Double-blind

Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills?

Dose: 20 g vs: placebo Outcome: throughout the protocol Effet: None P = 0.022

Population: healthy participants

Review

Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain …

Dose: 20 g/d vs: Placebo Outcome: None Effet: None None

Population: elderly

Cohort Study n=480

Decrease in Serum Vitamin D Level of Older Patients with Fatigue.

Dose: None vs: Control Outcome: Cognitive function Effet: None p=0.05

Population: patients with fatigue and 240 controls without fatigue,

Systematic Review n=281

Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized …

Dose: None vs: None Outcome: Cognitive function (memory, intelligence/reasoning) Effet: None None

Population: Healthy individuals

Key Statistics

Études

600

Participants

↑

Positive

Note

Referenced Papers

Creatine Supplementation and the Brain: Have We Put the Cart Before the Horse? Review

Journal of dietary … 2026

Analysis of Incidence and Clinical Characteristics of RSV Infection in Hospitalized Children: A Retrospective Study. Other

Risk management and … 2021 6 citations

Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills? RCT

Medicine and science … 2020 63 citations

Beyond sports: Efficacy and safety of creatine supplementation in pathological or paraphysiological conditions of brain and muscle. Review

Medicinal research reviews 2019 73 citations

Decrease in Serum Vitamin D Level of Older Patients with Fatigue. Other

Nutrients 2019 23 citations

Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Systematic Review

Experimental gerontology 2018 115 citations

Protein Supplementation During or Following a Marathon Run Influences Post-Exercise Recovery. RCT

Nutrients 2018 10 citations

Management of fibromyalgia: practical guides from recent evidence-based guidelines. Review

Polish archives of … 2017 95 citations

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 citations

Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients. Review

Medical hypotheses 2017 29 citations

A review of creatine supplementation in age-related diseases: more than a supplement for athletes. Review

F1000Research 2014 84 citations

Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation … CCT

Journal of translational … 2010 139 citations

Mental and physical fatigue-related biochemical alterations. RCT

Nutrition (Burbank, Los … 2009 85 citations

Effects of intense exercise on the physiological and mental condition of female university judoists during a training camp. Other

Journal of sports … 2008 36 citations

Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Other

Neuroscience research 2002 180 citations

Relationship of energy metabolism detected by 31P-MRS in the human brain with mental fatigue. Other

Neuropsychobiology 1999 23 citations

Stress hormonal factors, fatigue, and antioxidant responses to prolonged speed driving. Other

Pharmacology, biochemistry, and … 1998 60 citations

Central activation of autonomic effectors during mental simulation of motor actions in man. Other

The Journal of … 1993 334 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:: 3-5 g/day creatine monohydrate
cognitivesupport:: 5 g/day

Limite supérieure : 5 g/day considered safe for long-term use (ISSN position)

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Mixed	--
71.9%	24 weeks	Positive	--
20 g	--	Positive	--
20 g/d	--	Positive	--
None	--	Mixed	480
None	--	Positive	281
None	--	Positive	16
None	--	Positive	--

Moment optimal de prise : Any time of day; with or without food

Safety & Side Effects

Effets indésirables signalés

⚠ Water retention
⚠ Mild gastrointestinal discomfort
⚠ Weight gain (water weight)
⚠ Muscle cramping (rare, dose-dependent)

Interactions connues

● Nephrotoxic drugs (monitor kidney function with concurrent use)
● Caffeine (may partially attenuate creatine loading, debated)
● NSAIDs (theoretical additive kidney stress at high doses)

Apport maximal tolérable : 5 g/day considered safe for long-term use (ISSN position)

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Creatine help with Mental Fatigue?

Based on 8 studies with 600 participants, there is moderate evidence from clinical studies that Creatine may support Mental Fatigue management. Our evidence grade is B (Good Evidence).

How much Creatine should I take for Mental Fatigue?

Studies have used various dosages. A commonly studied range is 3-5 g/day creatine monohydrate. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Creatine?

Reported side effects may include Water retention, Mild gastrointestinal discomfort, Weight gain (water weight), Muscle cramping (rare, dose-dependent). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Creatine and Mental Fatigue?

We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Mental Fatigue

Rhodiola rosea B Panax Ginseng C

Creatine pour d'autres pathologies

Memory Loss C Sleep-Related Cognitive Impairment C

Verdict rapide

Evidence Strength72%

High confidence

Synthèse des études

RCT (3)Meta (0)Other (5)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Mental Fatigue

En savoir plus

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