Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

Airi Watanabe, Nobumasa Kato, Tadafumi Kato

Other Neuroscience research 2002 180 citations

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Study Design

Type d'étude: Controlled Clinical Trial
Taille de l'échantillon: 24
Population: Healthy adults

Intervention: Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Creatine 8g/day for 5 days
Comparateur: Placebo
Critère de jugement principal: Mental fatigue and cerebral hemoglobin oxygenation
Direction de l'effet: Positive
Risque de biais: Moderate

Abstract

While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain.

En bref

Using double-blind placebo-controlled paradigm, it is demonstrated that dietary supplement of creatine reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation.

Used In Evidence Reviews

B Creatine pour Mental Fatigue

Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

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Study Design

Abstract

En bref

Used In Evidence Reviews

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