Uridine Monophosphate untuk Neurotransmitter Imbalance

The uridine + DHA + choline combination (known as the 'Mr. Happy Stack') provides synergistic support for phospholipid synthesis and dopamine receptor expression. Limited but promising clinical evidence.

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Kesimpulan

Key Study Findings

Observational Study

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.

Dose: None vs: None Outcome: None Efek: None None

Populasi: Dogs with intervertebral disc herniation

In Vitro

The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites.

Dose: None vs: LPS-treated astrocyte controls Outcome: Astrocyte gene expression and metabolite changes Efek: None None

Populasi: LPS-induced inflammatory astrocyte model

Review

Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the …

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Other

1H and 31P magnetic resonance spectroscopy reveals potential pathogenic and biomarker metabolite alterations in Lafora …

Dose: None vs: None Outcome: None Efek: None P = 0.013

Populasi: Healthy adults

Other 4 weeks

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling …

Dose: 5 mg/kg vs: None Outcome: Cognitive function Efek: None None

Populasi: Sprague Dawley rats

In Vitro

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in …

Dose: 1 g vs: None Outcome: None Efek: None None

Populasi: None

Key Statistics

Studi

300

Peserta

↑

Positive

Peringkat

Referenced Papers

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. Other

Metabolites 2025

The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites. Other

Nutrients 2025

Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis. Review

Pharmacological reports : … 2025

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons. Other

Drug design, development … 2024 8 sitasi

1H and 31P magnetic resonance spectroscopy reveals potential pathogenic and biomarker metabolite alterations in Lafora disease. Other

Brain communications 2024 8 sitasi

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in the Chinese Mitten Crab, Eriocheir … Other

International journal of … 2023 12 sitasi

Citicoline for Supporting Memory in Aging Humans. Review

Aging and disease 2023 9 sitasi

Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function. Other

EMBO reports 2023 5 sitasi

The G Protein-Coupled Serotonin 1A Receptor Augments Protein Kinase Cε-Mediated Neurogenesis in Neonatal Mouse Hippocampus-PKCε-Mediated Signaling in the Early Hippocampus. Other

International journal of … 2022 4 sitasi

Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment. Other

Neurochemistry international 2021 12 sitasi

ATP as a cotransmitter in sympathetic and parasympathetic nerves - another Burnstock legacy. Other

Autonomic neuroscience : … 2021 9 sitasi

Dexamethasone-Induced Perturbations in Tissue Metabolomics Revealed by Chemical Isotope Labeling LC-MS analysis. Other

Metabolites 2020 29 sitasi

Vortioxetine: Clinical Pharmacokinetics and Drug Interactions. Review

Clinical pharmacokinetics 2018 128 sitasi

Loss of nitric oxide-mediated inhibition of purine neurotransmitter release in the colon in the absence of interstitial cells of Cajal. Other

American journal of … 2017 14 sitasi

Synapse formation in the brain can be enhanced by co-administering three specific nutrients. Other

European journal of … 2017 9 sitasi

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Other

Neurobiology of disease 2016 83 sitasi

Purinergic transmission in blood vessels. Review

Autonomic neuroscience : … 2015 81 sitasi

Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice. Other

Physiology & behavior 2015 45 sitasi

Optimising nutrition to improve growth and reduce neurodisabilities in neonates at risk of neurological impairment, and children with suspected or … RCT

BMC pediatrics 2015 15 sitasi

Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. Other

PloS one 2011 62 sitasi

Non-nutritional uses of nutrients. Review

European journal of … 2011 16 sitasi

Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats. Other

Stem cell research 2010 18 sitasi

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Other

Experimental neurology 2009 170 sitasi

Use of phosphatide precursors to promote synaptogenesis. Review

Annual review of … 2009 141 sitasi

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Review

Alzheimer's & dementia … 2008 96 sitasi

Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. Other

FASEB journal : … 2008 95 sitasi

Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors. Other

Journal of neurochemistry 2008 91 sitasi

Small-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells. Other

Biotechnology and applied … 2008 7 sitasi

HVC interneurons are not renewed in adult male zebra finches. Other

The European journal … 2007 55 sitasi

Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina. Other

The Journal of … 2007 36 sitasi

Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. Other

Journal of molecular … 2005 66 sitasi

P2X and P2Y receptors as possible targets of therapeutic manipulations in CNS illnesses. Review

Drug news & … 2005 43 sitasi

Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling … Other

Neuropsychopharmacology : official … 2005 39 sitasi

Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Other

Journal of neuroendocrinology 2002 83 sitasi

Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. Other

Journal of neuroscience … 2002 58 sitasi

Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients. Other

The Biochemical journal 2002 43 sitasi

Calcium-dependent regulation of cholinergic cell phenotype in the hypothalamus in vitro. Other

Journal of neurophysiology 2002 27 sitasi

Is there a role for uridine and pyrimidine nucleosides in the treatment of vascular dementia? Review

Functional neurology 2002

Identification and characterization of neuronal precursors and their progeny from human fetal tissue. Other

Journal of neuroscience … 2001 76 sitasi

Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations. Other

Hormones and behavior 2001 45 sitasi

Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. Other

The Journal of … 2000 745 sitasi

Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells. Other

The Journal of … 2000

Uridine activates fast transmembrane Ca2+ ion fluxes in rat brain homogenates. Other

Neuroreport 1999 32 sitasi

GABA, GAD, and GABA(A) receptor alpha4, beta1, and gamma1 subunits are expressed in the late embryonic and early postnatal neocortical … Other

Microscopy research and … 1998 26 sitasi

Neurogenesis and cell migration into the sexually dimorphic preoptic area/anterior hypothalamus of the fetal ferret. Other

Journal of neurobiology 1996 45 sitasi

In vitro properties of a newly established medulloblastoma cell line, MCD-1. Other

Molecular and chemical … 1996 17 sitasi

Ethanol neurotoxicity in culture: selective loss of cholinergic neurons. Other

Journal of neuroscience … 1996 16 sitasi

Sleep as neuronal detoxification and restitution. Review

Behavioural brain research 1995 146 sitasi

Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in … Other

Developmental biology 1989 100 sitasi

Adrenal steroids as modulators of nerve cell function. Review

Journal of steroid … 1984 22 sitasi

Neurons from fetal rat brain in a new cell culture system: a multidisciplinary analysis. Other

Brain research 1975 122 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 150-250 mg/day
cognitivesupport:: 250-500 mg sublingually

Batas atas: Not established; well-tolerated up to 1,000 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Neutral	--
5 mg/kg	4 weeks	Positive	--
1 g	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--

Waktu terbaik diminum: Morning; synergizes with DHA and choline sources

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Mild gastrointestinal discomfort
⚠ Headache (rare)
⚠ Nervousness at high doses

Interaksi yang Diketahui

● No significant drug interactions established

Asupan atas yang dapat ditoleransi: Not established; well-tolerated up to 1,000 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Uridine Monophosphate help with Neurotransmitter Imbalance?

Based on 4 studies with 300 participants, there is limited but promising evidence that Uridine Monophosphate may support Neurotransmitter Imbalance management. Our evidence grade is C (Some Evidence).

How much Uridine Monophosphate should I take for Neurotransmitter Imbalance?

Studies have used various dosages. A commonly studied range is 150-250 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Uridine Monophosphate?

Reported side effects may include Mild gastrointestinal discomfort, Headache (rare), Nervousness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Uridine Monophosphate and Neurotransmitter Imbalance?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Neurotransmitter Imbalance

Alpha-GPC B Zinc C

Kesimpulan Singkat

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (1)Meta (0)Other (3)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Neurotransmitter Imbalance

Pelajari Lebih Lanjut

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