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Schematic of calcium homeostasis disruption in aging neurons, depicting how mitochondrial calcium overload contributes to synaptic dysfunction and eventual neuronal death in Alzheimer's disease pathology.

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![Figure 15: Schematic of calcium homeostasis disruption in aging neurons, depicting how mitochondrial calcium overload contributes to synaptic dysfunction and eventual neuronal death in Alzheimer's disease pathology.]()

> Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." *Oxidative medicine and cellular longevity*, 2019. PMID: [31214285](https://pubmed.ncbi.nlm.nih.gov/31214285/)
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  <img src="" alt="Schematic of calcium homeostasis disruption in aging neurons, depicting how mitochondrial calcium overload contributes to synaptic dysfunction and eventual neuronal death in Alzheimer's disease pathology." />
  <figcaption>Figure 15. Schematic of calcium homeostasis disruption in aging neurons, depicting how mitochondrial calcium overload contributes to synaptic dysfunction and eventual neuronal death in Alzheimer's disease pathology.<br>  Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." <em>Oxidative medicine and cellular longevity</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31214285/">31214285</a></figcaption>
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