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Illustration of the blood-brain barrier crossing mechanisms for small-molecule antioxidants, depicting passive diffusion, carrier-mediated transport, and nanoparticle delivery strategies.

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![Figure 19: Illustration of the blood-brain barrier crossing mechanisms for small-molecule antioxidants, depicting passive diffusion, carrier-mediated transport, and nanoparticle delivery strategies.]()

> Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." *Oxidative medicine and cellular longevity*, 2019. PMID: [31214285](https://pubmed.ncbi.nlm.nih.gov/31214285/)
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  <img src="" alt="Illustration of the blood-brain barrier crossing mechanisms for small-molecule antioxidants, depicting passive diffusion, carrier-mediated transport, and nanoparticle delivery strategies." />
  <figcaption>Figure 19. Illustration of the blood-brain barrier crossing mechanisms for small-molecule antioxidants, depicting passive diffusion, carrier-mediated transport, and nanoparticle delivery strategies.<br>  Source: Imane Lejri et al. "Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Rel." <em>Oxidative medicine and cellular longevity</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31214285/">31214285</a></figcaption>
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