Zinc ： Neurotransmitter Imbalance

Zinc is essential for NMDA and GABA receptor modulation, synaptic plasticity, and BDNF signaling. Research suggests deficiency clearly impairs cognitive function and neurotransmitter balance.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'braincited.com'; const params = 'ingredient\u003Dzinc\u0026condition\u003Dneurotransmitter\u002Dimbalance'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

結論

Zinc is essential for NMDA and GABA receptor modulation, synaptic plasticity, and BDNF signaling. Research suggests deficiency clearly impairs cognitive function and neurotransmitter balance.

Key Study Findings

Review

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications.

Dose: None vs: None Outcome: association between zinc homeostasis and MDD pathology 効果: None None

対象集団: patients with major depressive disorder

Review

Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review.

Dose: None vs: None Outcome: None 効果: None None

対象集団: People with depression

Other

Exogenous nanomolar zinc ion (Zn2+) as a negative modulator of neuromuscular transmission via presynaptic mechanism …

Dose: Nanomolar range vs: Without Zn2+ addition Outcome: Neuromuscular transmission and diaphragm function 効果: None None

対象集団: Mouse diaphragm (ex vivo and in vivo)

Review

Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Observational Study

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Dogs with intervertebral disc herniation

Review

Magnesium and Zinc in Schizophrenia.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Patients with schizophrenia

Key Statistics

研究数

600

参加者数

↑

Positive

グレード

Referenced Papers

The role of zinc homeostasis in major depressive disorder: heterogeneous pathological mechanisms and therapeutic implications. Review

Annals of medicine 2026 1 件の引用

Botulinum Neurotoxins: History, Mechanism, and Applications. A Narrative Review. Review

Journal of neurochemistry 2025 8 件の引用

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature. Review

American journal of … 2025 3 件の引用

The Role of Various Types of Diets in the Treatments of Depressive Disorders. Review

Medicina (Kaunas, Lithuania) 2025 1 件の引用

Magnesium and Zinc in Schizophrenia. Review

Biomedicines 2025

Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions. Other

Nature communications 2025

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. Other

Metabolites 2025

Mineral Homeostasis and Depression: Implications for Prevention and Therapeutic Support-A Narrative Review. Review

International journal of … 2025

Exogenous nanomolar zinc ion (Zn2+) as a negative modulator of neuromuscular transmission via presynaptic mechanism in mouse diaphragm. Other

Biometals : an … 2025

Structure of the human dopamine transporter and mechanisms of inhibition. Other

Nature 2024 40 件の引用

Molecular mechanisms of zinc oxide nanoparticles neurotoxicity. Review

Chemico-biological interactions 2024 14 件の引用

Three classes of propofol binding sites on GABAA receptors. Other

The Journal of … 2024 9 件の引用

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons. Other

Drug design, development … 2024 8 件の引用

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies. Review

International journal of … 2024 7 件の引用

Manganese- and zinc-coordinated interaction of Schistosoma japonicum glutathione S-transferase with neurotransmitter transporters GlyT1 and GAT3 in vitro. Other

Experimental parasitology 2024 2 件の引用

Zinc or/and Vitamin E Supplementation Mitigates Oxidative Stress, Neuroinflammation, Neurochemical Changes and Behavioural Deficits in Male Wistar Rats Exposed to … Other

Journal of toxicology 2024 1 件の引用

Consequences of Disturbing Manganese Homeostasis. Review

International journal of … 2023 120 件の引用

Mechanisms of Cadmium Neurotoxicity. Review

International journal of … 2023 105 件の引用

Depression in dementia with Lewy bodies: a critical update. Review

Journal of neural … 2023 22 件の引用

Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease. Review

Pharmacology & therapeutics 2023 11 件の引用

Metabolic and Cellular Compartments of Acetyl-CoA in the Healthy and Diseased Brain. Review

International journal of … 2022 38 件の引用

Rebuilding essential active zone functions within a synapse. Other

Neuron 2022 29 件の引用

Neuronal signalling of zinc: from detection and modulation to function. Review

Open biology 2022 28 件の引用

Zinc alters behavioral phenotypes, neurotransmitter signatures, and immune homeostasis in male zebrafish (Danio rerio). Other

The Science of … 2022 11 件の引用

The Function and Regulation of Zinc in the Brain. Review

Neuroscience 2021 108 件の引用

The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized … Systematic Review

Nutrients 2021 37 件の引用

Zinc and Copper Brain Levels and Expression of Neurotransmitter Receptors in Two Rat ASD Models. Other

Frontiers in molecular … 2021 15 件の引用

A potential role for zinc in restless legs syndrome. Other

Sleep 2021 10 件の引用

Effects of Zinc, Mercury, or Lead on [3H]MK-801 and [3H]Fluorowillardiine Binding to Rat Synaptic Membranes. Other

Neurochemical research 2021 1 件の引用

Zinc. Review

Advances in food … 2021

Amperometric Measurements and Dynamic Models Reveal a Mechanism for How Zinc Alters Neurotransmitter Release. Other

Angewandte Chemie (International … 2020 28 件の引用

Copper deficiency anemia: review article. Review

Annals of hematology 2018 234 件の引用

[Nutrition strategies that improve cognitive function]. Review

Nutricion hospitalaria 2018 32 件の引用

Zinc transporter 3 (ZnT3) and vesicular zinc in central nervous system function. Review

Neuroscience and biobehavioral … 2017 138 件の引用

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies. Review

Frontiers in neuroscience 2017 58 件の引用

Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer. Review

Current pharmaceutical design 2017 37 件の引用

The zinc paradigm for metalloneurochemistry. Review

Essays in biochemistry 2017 19 件の引用

Smart Contrast Agents for Magnetic Resonance Imaging. Review

Chimia 2016 21 件の引用

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Other

Molecular nutrition & … 2015 18 件の引用

[Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms]. Other

Minerva ginecologica 2015 4 件の引用

Interaction of metal ions with neurotransmitter receptors and potential role in neurodiseases. Review

Biometals : an … 2014 72 件の引用

Cadmium and its neurotoxic effects. Review

Oxidative medicine and … 2013 520 件の引用

Glutamate receptors, neurotoxicity and neurodegeneration. Review

Pflugers Archiv : … 2010 1150 件の引用

Role of zinc in the development and treatment of mood disorders. Review

Current opinion in … 2010 77 件の引用

RNA oxidation and zinc in hepatic encephalopathy and hyperammonemia. Review

Metabolic brain disease 2009 42 件の引用

Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus. Review

Neurotoxicity research 2008 121 件の引用

Metals and neurotoxicology. Review

The Journal of … 2007 245 件の引用

Zn2+ modulation of neurotransmitter transporters. Review

Handbook of experimental … 2006 22 件の引用

Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. Other

Journal of neuroscience … 2004 115 件の引用

[Essential trace metals and brain function]. Review

Yakugaku zasshi : … 2004 36 件の引用

Atypical neural messengers. Review

Trends in neurosciences 2001 285 件の引用

Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection. Review

Biochemistry. Biokhimiia 2000 110 件の引用

Bacterial toxins with intracellular protease activity. Review

Clinica chimica acta; … 2000 31 件の引用

Zinc and the central nervous system. Review

Progress in food … 1987 48 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 8-11 mg/day (RDA)
cognitivesupport:: 15-30 mg/day

上限量： 40 mg/day (GI effects, copper depletion above)

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Mixed	--
Nanomolar range	--	Negative	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--

推奨摂取タイミング： With meals to reduce GI effects; separate from iron by 2 hours

Safety & Side Effects

報告されている副作用

⚠ Nausea on empty stomach
⚠ Copper deficiency at chronic high doses
⚠ Metallic taste
⚠ Headache

既知の相互作用

● Antibiotics (quinolones, tetracyclines — reduced absorption)
● Penicillamine (reduced absorption of both)
● Iron supplements (competitive absorption)

耐容上限摂取量： 40 mg/day (GI effects, copper depletion above)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Zinc help with Neurotransmitter Imbalance?

Based on 8 studies with 600 participants, there is limited but promising evidence that Zinc may support Neurotransmitter Imbalance management. Our evidence grade is C (Some Evidence).

How much Zinc should I take for Neurotransmitter Imbalance?

Studies have used various dosages. A commonly studied range is 8-11 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Zinc?

Reported side effects may include Nausea on empty stomach, Copper deficiency at chronic high doses, Metallic taste, Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Zinc and Neurotransmitter Imbalance?

We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Neurotransmitter Imbalance

Alpha-GPC B Uridine Monophosphate C

総合評価

Zinc is essential for NMDA and GABA receptor modulation, synaptic plasticity, and BDNF signaling. Research suggests deficiency clearly impairs cognitive function and neurotransmitter balance.

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (0)Meta (0)Other (8)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Neurotransmitter Imbalance

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。