설명
RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms.
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Figure 5
Subcellular distribution of PKC isoforms between cytosolic and membrane fractions is analyzed, showing altered translocation patterns in aged brain tissue.
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Figure 7
Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction.
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Figure 8
Quantitative densitometry of PKC isoform bands confirms statistically significant declines in neuroprotective PKC levels with advancing age.
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Figure 9
Activated PKC translocation to membrane fractions is diminished in aged rats, with reduced binding to RACK scaffolding proteins contributing to impaired neuroprotective signaling.
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Figure 10
Schematic representation of PKC isoform and RACK protein distribution in membrane fractions of young versus aged rat hippocampus illustrates the age-dependent loss of neuroprotective mechanisms.
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Figure 11
RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions.
chartFigure 6
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Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection.Cite This Figure
 > Source: Donatella Pastore et al. "Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mech." *International journal of molecular sciences*, 2019. PMID: [31331067](https://pubmed.ncbi.nlm.nih.gov/31331067/)
<figure> <img src="https://pdfs.citedhealth.com/figures/31331067/69.png" alt="RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms." /> <figcaption>Figure 6. RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms.<br> Source: Donatella Pastore et al. "Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mech." <em>International journal of molecular sciences</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31331067/">31331067</a></figcaption> </figure>