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Assessment of endothelial function following SIRT1 pharmacological activation in MTHFR-deficient conditions. Vasorelaxation responses indicate that SIRT1 activation may partially rescue the impaired vascular reactivity observed in MTHFR deficiency.

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![Figure 2: Assessment of endothelial function following SIRT1 pharmacological activation in MTHFR-deficient conditions. Vasorelaxation responses indicate that SIRT1 activation may partially rescue the impaired vascular reactivity observed in MTHFR deficiency.]()

> Source: Albino Carrizzo et al. "SIRT1 pharmacological activation rescues vascular dysfunction and prevents throm." *Cellular and molecular life sciences : CMLS*, 2022. PMID: [35821533](https://pubmed.ncbi.nlm.nih.gov/35821533/)
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  <img src="" alt="Assessment of endothelial function following SIRT1 pharmacological activation in MTHFR-deficient conditions. Vasorelaxation responses indicate that SIRT1 activation may partially rescue the impaired vascular reactivity observed in MTHFR deficiency." />
  <figcaption>Figure 2. Assessment of endothelial function following SIRT1 pharmacological activation in MTHFR-deficient conditions. Vasorelaxation responses indicate that SIRT1 activation may partially rescue the impaired vascular reactivity observed in MTHFR deficiency.<br>  Source: Albino Carrizzo et al. "SIRT1 pharmacological activation rescues vascular dysfunction and prevents throm." <em>Cellular and molecular life sciences : CMLS</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35821533/">35821533</a></figcaption>
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