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Figure 4

Описание

Electrophysiology or binding affinity data for propofol at different GABAA receptor binding sites, comparing potency across the three identified site classes.

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Mutagenesis or competition binding data supporting the classification of three distinct propofol binding site classes on GABAA receptors.

Figure 5

Mutagenesis or competition binding data supporting the classification of three distinct propofol binding site classes on GABAA receptors.

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Structure-activity relationship analysis of propofol analogs at the different GABAA receptor binding sites, informing anesthetic drug design.

Figure 6

Structure-activity relationship analysis of propofol analogs at the different GABAA receptor binding sites, informing anesthetic drug design.

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Molecular dynamics simulation or computational modeling of propofol interactions with GABAA receptor transmembrane domains.

Figure 7

Molecular dynamics simulation or computational modeling of propofol interactions with GABAA receptor transmembrane domains.

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Comparative analysis of propofol binding site occupancy and functional consequences for GABAA receptor channel gating and anesthetic efficacy.

Figure 8

Comparative analysis of propofol binding site occupancy and functional consequences for GABAA receptor channel gating and anesthetic efficacy.

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Supplementary structural or pharmacological data supporting the three-class model of propofol binding to GABAA receptors.

Figure 9

Supplementary structural or pharmacological data supporting the three-class model of propofol binding to GABAA receptors.

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Synthetic scheme for the preparation of cumene-d11 from benzene-d6, used as a deuterated propofol analog for binding site characterization studies on GABAA receptors.

Figure 10

Synthetic scheme for the preparation of cumene-d11 from benzene-d6, used as a deuterated propofol analog for binding site characterization studies on GABAA receptors.

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Figure 4

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Source Paper

Three classes of propofol binding sites on GABAA receptors.

The Journal of biological chemistry (2024)

PMID: 39270821

DOI: 10.1016/j.jbc.2024.107778

Cite This Figure

![Figure 4: Electrophysiology or binding affinity data for propofol at different GABAA receptor binding sites, comparing potency across the three identified site classes.](https://pdfs.citedhealth.com/figures/39270821/108.png)

> Source: Zi-Wei Chen et al. "Three classes of propofol binding sites on GABAA receptors.." *The Journal of biological chemistry*, 2024. PMID: [39270821](https://pubmed.ncbi.nlm.nih.gov/39270821/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/39270821/108.png" alt="Electrophysiology or binding affinity data for propofol at different GABAA receptor binding sites, comparing potency across the three identified site classes." />
  <figcaption>Figure 4. Electrophysiology or binding affinity data for propofol at different GABAA receptor binding sites, comparing potency across the three identified site classes.<br>  Source: Zi-Wei Chen et al. "Three classes of propofol binding sites on GABAA receptors.." <em>The Journal of biological chemistry</em>, 2024. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/39270821/">39270821</a></figcaption>
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