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Figure 2. γPKC, δPKC and εPKC levels in hippocampus of young (Y), middle-aged (M), and aged rats (O). Western Blot analysis of γPKC, δPKC and εPKC levels in the soluble and particulate fractions of young, middle-aged, and old rats hippocampus. γPKC levels
Figure 7. Figure 2. γPKC, δPKC and εPKC levels in hippocampus of young (Y), middle-aged (M), and aged rats (O). Western Blot analysis of γPKC, δPKC and εPKC levels in the soluble and particulate fractions of young, middle-aged, and old rats hippocampus. γPKC levels in the soluble fraction were significantly lower in old and middle-aged rats when compared to young rats, while no significant differences were present in particulate fraction (a). δPKC levels differ significantly between young and old rats in the soluble fraction while no significant differences were present in the particulate fraction (b). εPKC levels were significantly lower in the soluble fraction of old and middle-aged rat hippocampus compared to levels in young hippocampus. Also, εPKC levels were lower in the particulate fraction of old rat hippocampus compared to the young and middle-age groups (c). * p < 0.05 compared to the young group for γPKC, # p < 0.02 compared to the young group for γPKC, * p <

Açıklama

Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction.

More Figures from This Paper

Subcellular distribution of PKC isoforms between cytosolic and membrane fractions is analyzed, showing altered translocation patterns in aged brain tissue.

Figure 5

Subcellular distribution of PKC isoforms between cytosolic and membrane fractions is analyzed, showing altered translocation patterns in aged brain tissue.

chart
RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms.

Figure 6

RACK1 and RACK2 scaffolding protein levels are measured in aging hippocampus, indicating reduced anchoring capacity for activated PKC isoforms.

chart
Quantitative densitometry of PKC isoform bands confirms statistically significant declines in neuroprotective PKC levels with advancing age.

Figure 8

Quantitative densitometry of PKC isoform bands confirms statistically significant declines in neuroprotective PKC levels with advancing age.

chart
Activated PKC translocation to membrane fractions is diminished in aged rats, with reduced binding to RACK scaffolding proteins contributing to impaired neuroprotective signaling.

Figure 9

Activated PKC translocation to membrane fractions is diminished in aged rats, with reduced binding to RACK scaffolding proteins contributing to impaired neuroprotective signaling.

chart
Schematic representation of PKC isoform and RACK protein distribution in membrane fractions of young versus aged rat hippocampus illustrates the age-dependent loss of neuroprotective mechanisms.

Figure 10

Schematic representation of PKC isoform and RACK protein distribution in membrane fractions of young versus aged rat hippocampus illustrates the age-dependent loss of neuroprotective mechanisms.

diagram
RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions.

Figure 11

RACK1 and RACK2 protein levels in hippocampal tissue are quantified by Western blot across three age groups, with both scaffolding proteins showing age-related reductions.

chart

Figure 7

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Source Paper

Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection.

International journal of molecular sciences (2019)

PMID: 31331067

DOI: 10.3390/ijms20143544

Cite This Figure

![Figure 7: Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction.](https://pdfs.citedhealth.com/figures/31331067/124.png)

> Source: Donatella Pastore et al. "Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mech." *International journal of molecular sciences*, 2019. PMID: [31331067](https://pubmed.ncbi.nlm.nih.gov/31331067/)
<figure>
  <img src="https://pdfs.citedhealth.com/figures/31331067/124.png" alt="Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction." />
  <figcaption>Figure 7. Western blot analysis of gamma, delta, and epsilon PKC levels in hippocampus across young, middle-aged, and aged rats demonstrates progressive age-related reduction.<br>  Source: Donatella Pastore et al. "Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mech." <em>International journal of molecular sciences</em>, 2019. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/31331067/">31331067</a></figcaption>
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