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Figure 5

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Illustration of zinc and manganese transport and regulatory mechanisms in the central nervous system, highlighting how disruptions in metal ion balance may accelerate neurodegenerative processes.

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Molecular pathways of iron metabolism and ferroptosis in the context of neurodegenerative disease. Excessive iron accumulation in neurons can trigger lipid peroxidation and cell death through ferroptotic mechanisms.

Figure 3

Molecular pathways of iron metabolism and ferroptosis in the context of neurodegenerative disease. Excessive iron accumulation in neurons can trigger lipid peroxidation and cell death through ferroptotic mechanisms.

diagram
Schematic of copper homeostasis and cuproptosis mechanisms relevant to neurodegeneration. Copper imbalance has been implicated in the pathogenesis of Wilson's disease and may contribute to Alzheimer's disease progression.

Figure 4

Schematic of copper homeostasis and cuproptosis mechanisms relevant to neurodegeneration. Copper imbalance has been implicated in the pathogenesis of Wilson's disease and may contribute to Alzheimer's disease progression.

diagram
Summary of therapeutic strategies targeting metal ion dysregulation in neurodegenerative diseases, including iron chelation, antioxidant supplementation, and metal transporter modulation.

Figure 6

Summary of therapeutic strategies targeting metal ion dysregulation in neurodegenerative diseases, including iron chelation, antioxidant supplementation, and metal transporter modulation.

diagram
Integrative model linking metal ion imbalance to multiple neurodegenerative disease mechanisms including oxidative stress, ferroptosis, cuproptosis, cellular senescence, and neuroinflammation.

Figure 7

Integrative model linking metal ion imbalance to multiple neurodegenerative disease mechanisms including oxidative stress, ferroptosis, cuproptosis, cellular senescence, and neuroinflammation.

diagram

Figure 5

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Source Paper

Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases.

Signal transduction and targeted therapy (2025)

PMID: 39894843

DOI: 10.1038/s41392-024-02071-0

Cite This Figure

![Figure 5: Illustration of zinc and manganese transport and regulatory mechanisms in the central nervous system, highlighting how disruptions in metal ion balance may accelerate neurodegenerative processes.](https://pdfs.citedhealth.com/figures/39894843/686.png)

> Source: Leilei Chen et al. "Homeostasis and metabolism of iron and other metal ions in neurodegenerative dis." *Signal transduction and targeted therapy*, 2025. PMID: [39894843](https://pubmed.ncbi.nlm.nih.gov/39894843/)
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  <img src="https://pdfs.citedhealth.com/figures/39894843/686.png" alt="Illustration of zinc and manganese transport and regulatory mechanisms in the central nervous system, highlighting how disruptions in metal ion balance may accelerate neurodegenerative processes." />
  <figcaption>Figure 5. Illustration of zinc and manganese transport and regulatory mechanisms in the central nervous system, highlighting how disruptions in metal ion balance may accelerate neurodegenerative processes.<br>  Source: Leilei Chen et al. "Homeostasis and metabolism of iron and other metal ions in neurodegenerative dis." <em>Signal transduction and targeted therapy</em>, 2025. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/39894843/">39894843</a></figcaption>
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