Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials.

Xiao-Wei Zhang, Wen-Shang Hou, Min Li, Zhen-Yu Tang

Meta-Analysis Aging clinical and experimental research 2016 55 trích dẫn

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Loại nghiên cứu: Meta-Analysis
Đối tượng nghiên cứu: Elderly at risk of cognitive decline

Can thiệp: Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials. omega-3 fatty acids
Đối chứng: placebo or no treatment
Kết quả chính: cognitive decline in elderly
Xu hướng hiệu quả: Neutral
Nguy cơ sai lệch: Moderate

Abstract

Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library (updated to December 2014) was performed. We retrieved six randomized controlled studies as eligible for our meta-analysis. Among these six studies, the duration time ranged from 3 to 40 months. The dose of omega-3 fatty acids (DHA + EPA) ranged from 400 to 1800 mg. The result of our meta-analysis expressed that omega-3 fatty acids statistically decrease the rate of cognitive decline in MMSE score (WMD = 0.15, [0.05, 0.25]; p = 0.003). In conclusion, our meta-analysis indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly.

Tóm lược

It is indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly and statistically decrease the rate of Cognitive decline in MMSE score.

Used In Evidence Reviews

A Omega-3 Fatty Acids (DHA/EPA) cho Age-Related Cognitive Decline

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials.

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Abstract

Tóm lược

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