ALSUntangled #73: Lion's Mane.

Maya Muhanna, Issac Lund, Mark Bromberg, Paul Wicks, Michael Benatar et al.

Other Amyotrophic lateral sclerosis & frontotemporal degeneration 2024 2 trích dẫn

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Study Design

Loại nghiên cứu: Review
Đối tượng nghiên cứu: ALS patients (limited evidence)

Can thiệp: ALSUntangled #73: Lion's Mane. Hericium erinaceus (Lion's Mane)
Đối chứng: None
Kết quả chính: Neuroprotection and ALS progression
Xu hướng hiệu quả: Neutral
Nguy cơ sai lệch: Unclear

Abstract

Lion's Mane (Hericium erinaceus) has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion's Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion's Mane mushroom. Currently, we do not have enough information to support the use of Lion's Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.

Tóm lược

There are no studies in ALS cell or animal models or in humans with ALS, and currently, there do not have enough information to support the use of Lion’s Mane for treating ALS.

Used In Evidence Reviews

B Lion's Mane Mushroom cho Mild Cognitive Impairment (MCI)

C Lion's Mane Mushroom cho Brain Fog

ALSUntangled #73: Lion's Mane.

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Abstract

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Used In Evidence Reviews

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