Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.

T Horie, M Nakamaru, Y Masubuchi

Other Life sciences 1998 35 trích dẫn

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Loại nghiên cứu: In Vitro
Đối tượng nghiên cứu: animal model

Can thiệp: Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. None
Đối chứng: None
Kết quả chính: gut health
Xu hướng hiệu quả: Mixed
Nguy cơ sai lệch: Unclear

Abstract

Oral administration of methotrexate (MTX) to mice causes the damage of small intestine. The permeability of poorly absorbable compound fluorescein isothiocyanate (FITC)-labeled dextran (average molecular weight, 4,400) through the small intestine was studied in vitro using everted segments of the small intestine. The permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester (DHA) protected the small intestine from the increase in the small intestinal permeability induced by the MTX treatment. The MTX treatment decreased retinol concentration in plasma of mice and the coadministration of DHA maintained its concentration to the level of control mice. The present study showed that DHA protected the small intestine of mice from the MTX-induced damage.

Tóm lược

DHA protected the small intestine of mice from theMTX-induced damage and the permeability of FITC-dextran increased remarkably in the MTX-treated mice and oral administration of docosahexaenoic acid ethyl ester protected thesmall intestine from the increase in the small intestinal permeability.

Used In Evidence Reviews

C Omega-3 Fatty Acids (DHA/EPA) cho Attention & Focus Difficulties

Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice.

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Study Design

Abstract

Tóm lược

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