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Randomized Controlled Trials

Gold-standard experimental studies with random treatment allocation.

Use of Citicoline in Attention-Deficit/Hyperactivity Disorder: A Pilot Study.

Clinical neuropharmacology 2 citations

Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With N-Acetyl Cysteine.

The Journal of head trauma rehabilitation

Neuroprotective Effects of Alpha-Lipoic Acid Against Behavioral Toxicity, Oxidative and Inflammatory Damage Caused by Titanium Dioxide Nanoparticles.

Biological trace element research 2026 2 citations

Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment and Early Alzheimer Disease: Protocol for an Exploratory Double-Blind, Randomized, Placebo-Controlled Trial.

JMIR research protocols 2026

Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in relation to constitution (Prakriti) in healthy adults: clinical trial protocol.

Frontiers in medicine 2026

The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial.

Nutrients 2025 6 citations

Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research.

Asian Pacific journal of allergy and immunology 2025 6 citations

Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam.

Clinical, cosmetic and investigational dermatology 2025 4 citations

Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial.

The American journal of clinical nutrition 2025 2 citations

Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial.

PloS one 2025 1 citation

Centella asiatica improves sleep quality and quantity in aged mice.

bioRxiv : the preprint server for biology 2025 1 citation

Vitamin B12 supplementation attenuates endoplasmic reticulum stress and neuronal cell death in the cerebral cortex of high-fat high-sucrose-fed male mice.

Nutrition (Burbank, Los Angeles County, Calif.) 2025

Comparing the Efficacy of Combined Intralesional Triamcinolone Acetonide With Topical Calcipotriol Versus Intralesional Triamcinolone Acetonide Monotherapy in Scalp and Beard Alopecia Areata: Results From a Randomized Single-Blinded Clinical Trial.

Journal of cutaneous medicine and surgery 2025

Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac tissues and promotes neuroinflammation, with partial attenuation by taurine.

Neurotoxicology 2025

CMX-2043 Treatment Limits Neural Injury Pathophysiology and Promotes Neurological and Cognitive Recovery in a Pediatric Porcine Traumatic Brain Injury Model.

Journal of neurotrauma 2025

[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on network pharmacology and experiment].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2025

Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women.

Journal of applied physiology (Bethesda, Md. : 1985) 2025

Pharmacodynamic and Clinical Effects of Ginkgo Biloba Extract EGb 761 and Its Phytochemical Components in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD 2024 12 citations

Fish and Omega-3 Fatty Acids: Sex and Racial Differences in Cardiovascular Outcomes and Cognitive Function.

Arteriosclerosis, thrombosis, and vascular biology 2024 12 citations

Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.

International journal of molecular sciences 2024 11 citations

Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition-A Narrative Review.

Nutrients 2024 7 citations

Sex differences in lipid mediators derived from omega-3 fatty acids in older individuals with low-grade chronic inflammation.

Prostaglandins, leukotrienes, and essential fatty acids 2024 6 citations

The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial.

The journal of nutrition, health & aging 2024 6 citations

Comparative study of choline alfoscerate as a combination therapy with donepezil: A mixed double-blind randomized controlled and open-label observation trial.

Medicine 2024 3 citations

Clinical efficacy and mechanism of Ginkgo biloba extract in the treatment of elderly ischemic cerebrovascular disease.

Pakistan journal of pharmaceutical sciences 2024 2 citations

Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine.

International journal of molecular sciences 2024 1 citation

Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study.

Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 2024 1 citation

Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.

Journal of Parkinson's disease 2024 1 citation

A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress.

Scientific reports 2023 30 citations

Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.

Annals of neurology 2023 15 citations

Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment.

Nutricion hospitalaria 2023 13 citations

Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults.

Nutrients 2023 12 citations

A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive Performance of Healthy Adults with Self-Perceived Memory Problems.

Neurology and therapy 2023 9 citations

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.

Frontiers in neuroscience 2023 5 citations

Polo-like kinase inhibitor BI2536 induces eryptosis.

Wiener medizinische Wochenschrift (1946) 2023 4 citations

Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus.

Neuroscience letters 2023 4 citations

Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and immunohistochemical study.

Archives of dermatological research 2023 3 citations

Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study.

Frontiers in nutrition 2023 3 citations

Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled trial.

PloS one 2023

Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial.

Clinical nutrition (Edinburgh, Scotland) 2022 87 citations

Omega-3 fatty acids and blood-based biomarkers in Alzheimer's disease and mild cognitive impairment: A randomized placebo-controlled trial.

Brain, behavior, and immunity 2022 64 citations

Zinc alters behavioral phenotypes, neurotransmitter signatures, and immune homeostasis in male zebrafish (Danio rerio).

The Science of the total environment 2022 11 citations

Alpha lipoic acid reverses scopolamine-induced spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of Wistar rats.

IBRO neuroscience reports 2022 11 citations

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway.

Acta biochimica Polonica 2022 10 citations

A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine.

Nutrients 2022 9 citations

α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the β-Amyloid Accumulation.

Journal of inflammation research 2022 9 citations

Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its active ingredients under conditions of glycerol fatty acid ester as emulsifiers.

Journal of ethnopharmacology 2022 8 citations

N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study.

The journal of trauma and acute care surgery 2022 7 citations

Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a rat model.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2022 6 citations

Ginkgo biloba extract 761 reduces vascular permeability of the ovary and improves the symptom of ovarian hyperstimulation syndrome in a rat model.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2022 5 citations

Protection against Morphine-Induced Inhibitory Avoidance Memory Impairment in Rat by Curcumin: Possible Role of Nitric Oxide/ cAMP-Response Element Binding Protein Pathway.

Iranian journal of medical sciences 2022 5 citations

Comparative Study Between Intralesional Injection Of Platelet Rich Plasma And Intra Lesional Triamcinolone For The Treatment Of Alopecia Areata.

Journal of Ayub Medical College, Abbottabad : JAMC 2022 4 citations

Influence of a 12-Month Structured Exercise Program on the Micronutrient-Cognitive Fitness-Physical Association Profiles in Mild Cognitive Impairment.

Journal of Alzheimer's disease reports 2022 4 citations

Combination of platelet-rich plasma and platelet gel in treatment of resistance androgenic alopecia: A case series study.

Journal of cosmetic dermatology 2022 3 citations

Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by Bacopa monnieri.

Journal of complementary & integrative medicine 2022 3 citations

Curcumin improves reversal learning in middle-aged rhesus monkeys.

Behavioral neuroscience 2022 2 citations

Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.

NPJ Parkinson's disease 2022

Enhancement of Swimming Endurance by Herbal Supplement M3P.

Chinese journal of integrative medicine 2022

Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study.

Clinical nutrition (Edinburgh, Scotland) 2021 54 citations

Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation.

The journal of pain 2021 41 citations

Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants.

Journal of nutritional science 2021 26 citations

Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study.

Cells 2021 24 citations

Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment.

CNS & neurological disorders drug targets 2021 12 citations

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 120 citations

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial.

EBioMedicine 2020 107 citations

Can Creatine Combat the Mental Fatigue-associated Decrease in Visuomotor Skills?

Medicine and science in sports and exercise 2020 63 citations

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women.

Nutrients 2020 49 citations

Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.

Nutrients 2020 43 citations

Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT.

Scientific reports 2020 34 citations

Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity.

The Journal of nutrition 2020 33 citations

Comparative Evaluation of Therapeutic Efficacy of Intralesional Injection of Triamcinolone Acetonide versus Intralesional Autologous Platelet-rich Plasma Injection in Alopecia Areata.

Journal of cutaneous and aesthetic surgery 2020 21 citations

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study.

Reumatismo 2020 21 citations

Efficacy of Bacopa Monnieri (Brahmi) and Donepezil in Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Double-Blind Parallel Phase 2b Study.

Annals of Indian Academy of Neurology 2020 17 citations

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2020 5 citations

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.

Journal of psychiatric research 2019 46 citations

A Study to Compare the Efficacy of Platelet-rich Plasma and Minoxidil Therapy for the Treatment of Androgenetic Alopecia.

International journal of trichology 2019 41 citations

Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function in older women.

Prostaglandins, leukotrienes, and essential fatty acids 2019 5 citations

Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder.

Journal of child and adolescent psychopharmacology 2018 133 citations

Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise.

Nutrients 2018 108 citations

Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial.

Journal of the International Neuropsychological Society : JINS 2018 76 citations

Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Journal of Alzheimer's disease : JAD 2018 63 citations

Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin.

Advances in nutrition (Bethesda, Md.) 2018 28 citations

Effects of Omega-3 Fatty Acids on Resting Cerebral Perfusion in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial.

The journal of prevention of Alzheimer's disease 2018 24 citations

Immunotherapy of Mild Cognitive Impairment by ω-3 Supplementation: Why Are Amyloid-β Antibodies and ω-3 Not Working in Clinical Trials?

Journal of Alzheimer's disease : JAD 2018 12 citations

Protein Supplementation During or Following a Marathon Run Influences Post-Exercise Recovery.

Nutrients 2018 10 citations

Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder.

Journal of the American Academy of Child and Adolescent Psychiatry 2017 245 citations

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial.

Nutrients 2017 149 citations

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study.

Acta neuropsychiatrica 2017 84 citations

Resveratrol supplementation reduces pain experience by postmenopausal women.

Menopause (New York, N.Y.) 2017 47 citations

Phospholipid oxidation and carotenoid supplementation in Alzheimer's disease patients.

Free radical biology & medicine 2017 37 citations

Short-Term Impact of a Combined Nutraceutical on Cognitive Function, Perceived Stress and Depression in Young Elderly with Cognitive Impairment: A Pilot, Double-Blind, Randomized Clinical Trial.

The journal of prevention of Alzheimer's disease 2017 30 citations

Alopecia and platelet-derived therapies.

Stem cell investigation 2017 27 citations

Effects of sulforaphane and vitamin E on cognitive disorder and oxidative damage in lead-exposed mice hippocampus at lactation.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2017 24 citations

Memory Complaints and Cognitive Decline: Data from the GUIDAGE Study1.

Journal of Alzheimer's disease : JAD 2017 17 citations

Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD 2016 128 citations

Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment.

NeuroImage 2016 118 citations

Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus.

Nutrition, metabolism, and cardiovascular diseases : NMCD 2016 85 citations

Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus.

Nutrients 2016 83 citations

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults.

Nutrients 2016 53 citations

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.

Neurobiology of aging 2016 19 citations