Phosphatidylserine para Attention & Focus Difficulties

Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.

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Conclusión

Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.

Key Study Findings

Other

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …

Dose: 50 mg/kg lycopene in mice vs: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) Efecto: None None

Población: HFD-induced obese male C57BL/6 mice

In Vitro

The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential …

Dose: None vs: None Outcome: CMPF-induced eryptosis via PIEZO1 activation Efecto: None None

Población: Human red blood cells from healthy individuals

Other

Initiation of Progressive Morphological Transition Towards an Echino-Stomato-Spherocytic Phenotype by Phosphatidylserine Externalization and Its Implication …

Dose: None vs: Untreated erythrocytes Outcome: Erythrocyte morphological transition and thrombosis Efecto: None None

Población: Rat erythrocytes (in vitro/in vivo)

Other

Milk Fat Globules: 2024 Updates.

Dose: None vs: None Outcome: Inflammatory markers Efecto: None None

Población: None

Randomized Controlled Trial n=138 6.0 weeks Double-blind

A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract …

Dose: None vs: placebo Outcome: cognitive function Efecto: None p ≤ 0.024

Población: Adults with cognitive concerns

In Vitro

Concentration of Phosphatidylserine Influence Rates of Insulin Aggregation and Toxicity of Amyloid Aggregates In Vitro.

Dose: 40% vs: None Outcome: lipid levels Efecto: None None

Población: None

Key Statistics

Estudios

350

Participantes

↑

Positive

Calificación

Referenced Papers

The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential activation of PIEZO1. Other

Nephrology, dialysis, transplantation … 2025 3 citas

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. Other

Clinical nutrition (Edinburgh, … 2025 1 citas

Initiation of Progressive Morphological Transition Towards an Echino-Stomato-Spherocytic Phenotype by Phosphatidylserine Externalization and Its Implication in Thrombosis. Other

International journal of … 2025 1 citas

Milk Fat Globules: 2024 Updates. Other

Newborn (Clarksville, Md.) 2024 9 citas

A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive … Other

Neurology and therapy 2023 9 citas

Concentration of Phosphatidylserine Influence Rates of Insulin Aggregation and Toxicity of Amyloid Aggregates In Vitro. Other

ACS chemical neuroscience 2023 7 citas

Polo-like kinase inhibitor BI2536 induces eryptosis. Other

Wiener medizinische Wochenschrift … 2023 4 citas

Iodixanol supplementation in freezing extender improves the antioxidant capacity of semen. Other

Reproduction in domestic … 2023 1 citas

TMEM16F mediated phosphatidylserine exposure and microparticle release on erythrocyte contribute to hypercoagulable state in hyperuricemia. Other

Blood cells, molecules … 2022 12 citas

[Mechanism of Leakage in Phosphatidylserine-Containing Membranes by Melittin]. Other

Molekuliarnaia biologiia 2022

Effects of storage and leukocyte reduction on the concentration and procoagulant activity of extracellular vesicles in canine packed red cells. Other

Journal of veterinary … 2021 7 citas

Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. Other

Frontiers in medicine 2021 6 citas

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 citas

Intracellular Ca2+ Concentration and Phosphatidylserine Exposure in Healthy Human Erythrocytes in Dependence on in vivo Cell Age. Review

Frontiers in physiology 2019 20 citas

Extracellular vesicle concentration and procoagulant activity of canine haemoperitoneum fluid and packed red blood cells. Other

The Journal of … 2019 2 citas

Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. Other

Frontiers in psychology 2018 13 citas

Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches. Other

Oncotarget 2017 35 citas

Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine. Other

Cellular physiology and … 2017 17 citas

Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. Other

Biochimica et biophysica … 2017 1 citas

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 citas

Storage of Erythrocytes Induces Suicidal Erythrocyte Death. Other

Cellular physiology and … 2016 50 citas

Isolation and Analysis of Phospholipids in Dairy Foods. Review

Journal of analytical … 2016 49 citas

Role of tissue factor expression in thrombin generation by canine tumor cells. Other

American journal of … 2016 7 citas

Phosphatidylserine and the human brain. Review

Nutrition (Burbank, Los … 2015 149 citas

Enhanced suicidal erythrocyte death in acute cardiac failure. Other

European journal of … 2015 28 citas

Enhanced eryptosis following juglone exposure. Other

Basic & clinical … 2015 17 citas

[Molecular regulations of phosphatidylserine eversion in plasma membrane]. Review

Yi chuan = … 2015 4 citas

Quantitative analysis of annexin V-membrane interaction by flow cytometry. Other

European biophysics journal … 2015

Suicidal erythrocyte death in end-stage renal disease. Other

Journal of molecular … 2014 138 citas

Geldanamycin-induced phosphatidylserine translocation in the erythrocyte membrane. Other

Cellular physiology and … 2013 53 citas

Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity. Other

PloS one 2013 12 citas

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease. Other

Journal of Alzheimer's … 2012 257 citas

Phosphatidylserine dynamics in cellular membranes. Other

Molecular biology of … 2012 173 citas

Apigenin-induced suicidal erythrocyte death. Other

Journal of agricultural … 2012 33 citas

Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry. Other

Biometals : an … 2012

Stimulation of suicidal erythrocyte death by oridonin. Other

Archives of biochemistry … 2011 20 citas

Inhibition of suicidal erythrocyte death by blebbistatin. Other

American journal of … 2011 17 citas

Formation of procoagulant microparticles and properties. Review

Thrombosis research 2010 155 citas

Monensin induced suicidal erythrocyte death. Other

Cellular physiology and … 2010 51 citas

Differences in CSF phospholipid concentration by traumatic brain injury outcome. Other

Biological research for … 2010 49 citas

Lactadherin and clearance of platelet-derived microvesicles. Other

Blood 2009 204 citas

Arsenic-induced suicidal erythrocyte death. Other

Archives of toxicology 2009 78 citas

Vanadate-induced suicidal erythrocyte death. Other

Kidney & blood … 2008 62 citas

Suicidal death of erythrocytes due to selenium-compounds. Other

Cellular physiology and … 2008 46 citas

In vitro and in vivo characterization of a combination chemotherapy formulation consisting of vinorelbine and phosphatidylserine. Other

European journal of … 2007 34 citas

Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Review

Alternative medicine review … 2007

Enhanced programmed cell death of iron-deficient erythrocytes. Other

FASEB journal : … 2006 244 citas

Induction of eryptosis by cyclosporine. Other

Naunyn-Schmiedeberg's archives of … 2006 63 citas

Surface exposure of phosphatidylserine in pathological cells. Review

Cellular and molecular … 2005 747 citas

Erythrocyte ion channels in regulation of apoptosis. Review

Advances in experimental … 2004 29 citas

Metabolism and functions of phosphatidylserine in mammalian brain. Review

Neurochemical research 2003 82 citas

The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. CCT

Nutritional neuroscience 2001 66 citas

Oxidation and erythrocyte senescence. Review

Current opinion in … 2000 256 citas

A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Review

Alternative medicine review … 1999 112 citas

N-stearoyl-phosphatidylserine: synthesis and role in divalent-cation-induced aggregation and fusion. Other

Lipids 1998 6 citas

Interaction of bovine heart pyruvate kinase with phospholipids. Other

Biochimica et biophysica … 1995 7 citas

Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site? Other

Cell 1983 307 citas

Binding of monovalent cations to phosphatidylserine and modulation of Ca2+- and Mg2+-induced vesicle fusion. Other

Biochimica et biophysica … 1983 55 citas

Spectrin-phospholipid interaction. A monolayer study. Other

Biochimica et biophysica … 1980 118 citas

Fusion of phosphatidylserine and mixed phosphatidylserine-phosphatidylcholine vesicles. Dependence on calcium concentration and temperature. Other

Biochimica et biophysica … 1979 28 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 100 mg/day
cognitivesupport:: 100-300 mg/day

Límite superior: Well-tolerated up to 600 mg/day

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
50 mg/kg lycopene in mice	--	Positive	--
None	--	Negative	--
None	--	Negative	--
None	--	Positive	--
None	6.0 weeks	Mixed	138
40%	--	Mixed	--
None	--	Mixed	--
4 g	--	Mixed	--

Mejor momento para tomar: With meals for better absorption

Safety & Side Effects

Efectos secundarios reportados

⚠ Mild gastrointestinal discomfort
⚠ Insomnia at high doses
⚠ Rare allergic reactions (soy-derived forms)

Interacciones conocidas

● Anticholinergic medications (may reduce PS effectiveness)
● Blood thinners (theoretical interaction)
● Cholinesterase inhibitors (additive cholinergic effects)

Ingesta máxima tolerable: Well-tolerated up to 600 mg/day

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Phosphatidylserine help with Attention & Focus Difficulties?

Based on 5 studies with 350 participants, there is limited but promising evidence that Phosphatidylserine may support Attention & Focus Difficulties management. Our evidence grade is C (Some Evidence).

How much Phosphatidylserine should I take for Attention & Focus Difficulties?

Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Phosphatidylserine?

Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Phosphatidylserine and Attention & Focus Difficulties?

We rate the evidence as Grade C (Some Evidence). This rating is based on 5 peer-reviewed studies with 350 total participants. The overall direction of effect is positive.

Related Evidence

Otros ingredientes para Attention & Focus Difficulties

L-Theanine B Citicoline B Omega-3 Fatty Acids (DHA/EPA) C Bacopa monnieri C

Phosphatidylserine para otras condiciones

Age-Related Cognitive Decline B Stress-Induced Cognitive Decline C

Veredicto rápido

Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.

Evidence Strength52%

Moderate confidence

Desglose de estudios

RCT (1)Meta (0)Other (4)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Attention & Focus Difficulties

Más información

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.