Phosphatidylserine 관련 주의력 및 집중력 저하
C 근거 소규모 연구에서의 근거는 제한적이지만, 일부 긍정적인 신호가 존재합니다.Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.
결론
Research suggests phosphatidylserine may help support focus and reduce behaviors associated with attention difficulties, particularly in stressed individuals.
Key Study Findings
대상 집단: HFD-induced obese male C57BL/6 mice
대상 집단: Human red blood cells from healthy individuals
대상 집단: Rat erythrocytes (in vitro/in vivo)
대상 집단: None
대상 집단: Adults with cognitive concerns
대상 집단: None
Key Statistics
5
연구
350
참여자
Positive
등급
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 100 mg/day
- cognitivesupport:
- 100-300 mg/day
상한량: Well-tolerated up to 600 mg/day
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Negative | -- |
| None | -- | Negative | -- |
| None | -- | Positive | -- |
| None | 6.0 weeks | Mixed | 138 |
| 40% | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 4 g | -- | Mixed | -- |
권장 복용 시간: With meals for better absorption
Safety & Side Effects
보고된 부작용
- ⚠ Mild gastrointestinal discomfort
- ⚠ Insomnia at high doses
- ⚠ Rare allergic reactions (soy-derived forms)
알려진 상호작용
- ● Anticholinergic medications (may reduce PS effectiveness)
- ● Blood thinners (theoretical interaction)
- ● Cholinesterase inhibitors (additive cholinergic effects)
일일 최대 섭취 허용량: Well-tolerated up to 600 mg/day
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Phosphatidylserine help with 주의력 및 집중력 저하?
How much Phosphatidylserine should I take for 주의력 및 집중력 저하?
Are there side effects of Phosphatidylserine?
How strong is the evidence for Phosphatidylserine and 주의력 및 집중력 저하?
Related Evidence
관련 다른 성분: 주의력 및 집중력 저하
Phosphatidylserine 다른 건강 상태에 대한 근거
References
- [1] Beatriz Akemi Kondo Van Spitzenbergen et al.. Nephrol Dial Transplant. 2025. The uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) may enhance eryptosis and increase erythrocyte osmotic fragility through potential activation of PIEZO1. doi:10.1093/ndt/gfae275 PubMed
- [2] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
- [3] Yiying Bian et al.. Int J Mol Sci. 2025. Initiation of Progressive Morphological Transition Towards an Echino-Stomato-Spherocytic Phenotype by Phosphatidylserine Externalization and Its Implication in Thrombosis. doi:10.3390/ijms26041747 PubMed
- [4] Akhil Maheshwari et al.. Newborn (Clarksville). 2024. Milk Fat Globules: 2024 Updates. doi:10.5005/jp-journals-11002-0085 PubMed
- [5] Katarina M Doma et al.. Neurol Ther. 2023. A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive … doi:10.1007/s40120-023-00454-z PubMed
- [6] Mikhail Matveyenka et al.. ACS Chem Neurosci. 2023. Concentration of Phosphatidylserine Influence Rates of Insulin Aggregation and Toxicity of Amyloid Aggregates In Vitro. doi:10.1021/acschemneuro.3c00277 PubMed
- [7] Mohamed Jemaà et al.. Wien Med Wochenschr. 2023. Polo-like kinase inhibitor BI2536 induces eryptosis. doi:10.1007/s10354-022-00966-7 PubMed
- [8] Fernanda N Marqui et al.. Reprod Domest Anim. 2023. Iodixanol supplementation in freezing extender improves the antioxidant capacity of semen. doi:10.1111/rda.14470 PubMed
- [9] Meishan Yan et al.. Blood Cells Mol Dis. 2022. TMEM16F mediated phosphatidylserine exposure and microparticle release on erythrocyte contribute to hypercoagulable state in hyperuricemia. doi:10.1016/j.bcmd.2022.102666 PubMed
- [10] R Wang et al.. Mol Biol (Mosk). 2022. [Mechanism of Leakage in Phosphatidylserine-Containing Membranes by Melittin]. doi:10.31857/S0026898422060246 PubMed
- [11] Daniel Avenick et al.. J Vet Emerg Crit Care (San Antonio). 2021. Effects of storage and leukocyte reduction on the concentration and procoagulant activity of extracellular vesicles in canine packed red cells. doi:10.1111/vec.13050 PubMed
- [12] Sanja Lalic-Cosic et al.. Front Med (Lausanne). 2021. Phosphatidylserine Exposing Extracellular Vesicles in Pre-eclamptic Patients. doi:10.3389/fmed.2021.761453 PubMed
- [13] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
- [14] Ingolf Bernhardt et al.. Front Physiol. 2019. Intracellular Ca2+ Concentration and Phosphatidylserine Exposure in Healthy Human Erythrocytes in Dependence on in vivo Cell Age. doi:10.3389/fphys.2019.01629 PubMed
- [15] S Sowy et al.. J Small Anim Pract. 2019. Extracellular vesicle concentration and procoagulant activity of canine haemoperitoneum fluid and packed red blood cells. doi:10.1111/jsap.13002 PubMed
- [16] Durga Chapagain et al.. Front Psychol. 2018. Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. doi:10.3389/fpsyg.2018.02217 PubMed
- [17] Ségolène Hescot et al.. Oncotarget. 2017. Identifying mitotane-induced mitochondria-associated membranes dysfunctions: metabolomic and lipidomic approaches. doi:10.18632/oncotarget.18968 PubMed
- [18] Jasmin Egler et al.. Cell Physiol Biochem. 2017. Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine. doi:10.1159/000475977 PubMed
- [19] Audrey F Meyer et al.. Biochim Biophys Acta Biomembr. 2017. Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. doi:10.1016/j.bbamem.2017.04.027 PubMed
- [20] Philippa A Jackson et al.. Nutrients. 2016. DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … doi:10.3390/nu8020086 PubMed
- [21] Elisabeth Lang et al.. Cell Physiol Biochem. 2016. Storage of Erythrocytes Induces Suicidal Erythrocyte Death. doi:10.1159/000445657 PubMed
- [22] Lígia Pimentel et al.. J Anal Methods Chem. 2016. Isolation and Analysis of Phospholipids in Dairy Foods. doi:10.1155/2016/9827369 PubMed
- [23] Erika J Gruber et al.. Am J Vet Res. 2016. Role of tissue factor expression in thrombin generation by canine tumor cells. doi:10.2460/ajvr.77.4.404 PubMed
- [24] Michael J Glade et al.. Nutrition. 2015. Phosphatidylserine and the human brain. doi:10.1016/j.nut.2014.10.014 PubMed
- [25] Philipp Attanasio et al.. Eur J Clin Invest. 2015. Enhanced suicidal erythrocyte death in acute cardiac failure. doi:10.1111/eci.12555 PubMed
- [26] Salvatrice Calabrò et al.. Basic Clin Pharmacol Toxicol. 2015. Enhanced eryptosis following juglone exposure. doi:10.1111/bcpt.12340 PubMed
- [27] Dan Bi et al.. Yi Chuan. 2015. [Molecular regulations of phosphatidylserine eversion in plasma membrane]. doi:10.16288/j.yczz.14-207 PubMed
- [28] Jie Wang et al.. Eur Biophys J. 2015. Quantitative analysis of annexin V-membrane interaction by flow cytometry. doi:10.1007/s00249-015-1026-9 PubMed
- [29] Majed Abed et al.. J Mol Med (Berl). 2014. Suicidal erythrocyte death in end-stage renal disease. doi:10.1007/s00109-014-1151-4 PubMed
- [30] Kashif Jilani et al.. Cell Physiol Biochem. 2013. Geldanamycin-induced phosphatidylserine translocation in the erythrocyte membrane. doi:10.1159/000356596 PubMed
- [31] Antonio L Egea-Jiménez et al.. PLoS One. 2013. Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity. doi:10.1371/journal.pone.0069041 PubMed
- [32] Stephen C Cunnane et al.. J Alzheimers Dis. 2012. Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease. doi:10.3233/JAD-2012-110629 PubMed
- [33] Jason G Kay et al.. Mol Biol Cell. 2012. Phosphatidylserine dynamics in cellular membranes. doi:10.1091/mbc.E11-11-0936 PubMed
- [34] Mohanad Zbidah et al.. J Agric Food Chem. 2012. Apigenin-induced suicidal erythrocyte death. doi:10.1021/jf204107f PubMed
- [35] Adrian Lupescu et al.. Biometals. 2012. Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry. doi:10.1007/s10534-011-9507-5 PubMed
- [36] Kashif Jilani et al.. Arch Biochem Biophys. 2011. Stimulation of suicidal erythrocyte death by oridonin. doi:10.1016/j.abb.2011.05.001 PubMed
- [37] Elisabeth Lang et al.. Am J Physiol Cell Physiol. 2011. Inhibition of suicidal erythrocyte death by blebbistatin. doi:10.1152/ajpcell.00043.2011 PubMed
- [38] Jean-Marie Freyssinet et al.. Thromb Res. 2010. Formation of procoagulant microparticles and properties. doi:10.1016/j.thromres.2010.01.036 PubMed
- [39] Shefalee K Bhavsar et al.. Cell Physiol Biochem. 2010. Monensin induced suicidal erythrocyte death. doi:10.1159/000315094 PubMed
- [40] Alice E Pasvogel et al.. Biol Res Nurs. 2010. Differences in CSF phospholipid concentration by traumatic brain injury outcome. doi:10.1177/1099800409346056 PubMed
- [41] Swapan K Dasgupta et al.. Blood. 2009. Lactadherin and clearance of platelet-derived microvesicles. doi:10.1182/blood-2008-07-167148 PubMed
- [42] Hasan Mahmud et al.. Arch Toxicol. 2009. Arsenic-induced suicidal erythrocyte death. doi:10.1007/s00204-008-0338-2 PubMed
- [43] Michael Föller et al.. Kidney Blood Press Res. 2008. Vanadate-induced suicidal erythrocyte death. doi:10.1159/000119704 PubMed
- [44] Mentor Sopjani et al.. Cell Physiol Biochem. 2008. Suicidal death of erythrocytes due to selenium-compounds. doi:10.1159/000185452 PubMed
- [45] Murray S Webb et al.. Eur J Pharm Biopharm. 2007. In vitro and in vivo characterization of a combination chemotherapy formulation consisting of vinorelbine and phosphatidylserine. doi:10.1016/j.ejpb.2006.10.007 PubMed
- [46] Parris M Kidd. Altern Med Rev. 2007. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. PubMed
- [47] Daniela S Kempe et al.. FASEB J. 2006. Enhanced programmed cell death of iron-deficient erythrocytes. doi:10.1096/fj.05-4872fje PubMed
- [48] Olivier M Niemoeller et al.. Naunyn Schmiedebergs Arch Pharmacol. 2006. Induction of eryptosis by cyclosporine. doi:10.1007/s00210-006-0099-5 PubMed
- [49] R F A Zwaal et al.. Cell Mol Life Sci. 2005. Surface exposure of phosphatidylserine in pathological cells. doi:10.1007/s00018-005-4527-3 PubMed
- [50] Florian Lang et al.. Adv Exp Med Biol. 2004. Erythrocyte ion channels in regulation of apoptosis. doi:10.1007/0-387-23752-6_20 PubMed
- [51] Rita Mozzi et al.. Neurochem Res. 2003. Metabolism and functions of phosphatidylserine in mammalian brain. doi:10.1023/a:1022412831330 PubMed
- [52] B L Jorissen et al.. Nutr Neurosci. 2001. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. doi:10.1080/1028415x.2001.11747356 PubMed
- [53] C R Kiefer et al.. Curr Opin Hematol. 2000. Oxidation and erythrocyte senescence. doi:10.1097/00062752-200003000-00007 PubMed
- [54] P M Kidd. Altern Med Rev. 1999. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. PubMed
- [55] M Morillo et al.. Lipids. 1998. N-stearoyl-phosphatidylserine: synthesis and role in divalent-cation-induced aggregation and fusion. doi:10.1007/s11745-998-0247-1 PubMed
- [56] A Dabrowska et al.. Biochim Biophys Acta. 1995. Interaction of bovine heart pyruvate kinase with phospholipids. doi:10.1016/0005-2736(95)00061-7 PubMed
- [57] R Schlegel et al.. Cell. 1983. Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV-binding site? doi:10.1016/0092-8674(83)90483-x PubMed
- [58] S Nir et al.. Biochim Biophys Acta. 1983. Binding of monovalent cations to phosphatidylserine and modulation of Ca2+- and Mg2+-induced vesicle fusion. doi:10.1016/0005-2736(83)90271-7 PubMed
- [59] C Mombers et al.. Biochim Biophys Acta. 1980. Spectrin-phospholipid interaction. A monolayer study. doi:10.1016/0005-2736(80)90390-9 PubMed
- [60] S T Sun et al.. Biochim Biophys Acta. 1979. Fusion of phosphatidylserine and mixed phosphatidylserine-phosphatidylcholine vesicles. Dependence on calcium concentration and temperature. doi:10.1016/0005-2736(79)90088-9 PubMed
FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.