Description

Proposed signaling pathway illustrating how SIRT1 pharmacological activation rescues vascular dysfunction in MTHFR deficiency. The model integrates findings on endothelial function, thrombosis, inflammation, and oxidative stress into a mechanistic framework.

Figure 8

Diagram

Source Paper

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency.

Cellular and molecular life sciences : CMLS (2022)

PMID: 35821533

DOI: 10.1007/s00018-022-04429-5

Cite This Figure

![Figure 8: Proposed signaling pathway illustrating how SIRT1 pharmacological activation rescues vascular dysfunction in MTHFR deficiency. The model integrates findings on endothelial function, thrombosis, inflammation, and oxidative stress into a mechanistic framework.]()

> Source: Albino Carrizzo et al. "SIRT1 pharmacological activation rescues vascular dysfunction and prevents throm." *Cellular and molecular life sciences : CMLS*, 2022. PMID: [35821533](https://pubmed.ncbi.nlm.nih.gov/35821533/)

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  <img src="" alt="Proposed signaling pathway illustrating how SIRT1 pharmacological activation rescues vascular dysfunction in MTHFR deficiency. The model integrates findings on endothelial function, thrombosis, inflammation, and oxidative stress into a mechanistic framework." />
  <figcaption>Figure 8. Proposed signaling pathway illustrating how SIRT1 pharmacological activation rescues vascular dysfunction in MTHFR deficiency. The model integrates findings on endothelial function, thrombosis, inflammation, and oxidative stress into a mechanistic framework.<br>  Source: Albino Carrizzo et al. "SIRT1 pharmacological activation rescues vascular dysfunction and prevents throm." <em>Cellular and molecular life sciences : CMLS</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35821533/">35821533</a></figcaption>
</figure>

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