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Vitamin E pour Age-Related Cognitive Decline

C

High-dose vitamin E may slow functional decline in moderate Alzheimer's disease (TEAM-AD trial). Results are mixed for cognitive decline prevention in healthy populations.

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C

En conclusion

High-dose vitamin E may slow functional decline in moderate Alzheimer's disease (TEAM-AD trial). Results are mixed for cognitive decline prevention in healthy populations.

Key Study Findings

Systematic Review n=80488
Vitamin E and cognitive function: A systematic review of clinical evidence.
Dose: None vs: None Outcome: cognitive function / cognitive impairment Effet: None None

Population: participants from 43 clinical studies (2012-2022)

Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d vs: None Outcome: Cognitive decline in AD Effet: None None

Population: Alzheimer's disease patients

Observational Study n=2713 Open-label
Non-linear association between dietary fiber intake and cognitive function mediated by vitamin E: a cross-sectional …
Dose: Inflection at 29.65 g/day (DSST), 22.65 g/day (composite) vs: Cross-sectional fiber intake groups Outcome: Cognitive function composite z-scores (DSST, AFT, CERAD) Effet: β=0.18 per unit fiber below inflection <0.0001

Population: NHANES adults aged ≥60 years (2011-2014)

Review
The Role of Vitamins in Neurodegeneration: A Brief Review of Mechanisms, Clinical Evidence, and Therapeutic …
Dose: None vs: None Outcome: None Effet: None None

Population: Review of vitamins in neurodegeneration

Review
Bioactive compounds and dietary patterns in Alzheimer's disease.
Dose: None vs: None Outcome: AD progression and cognitive decline Effet: None None

Population: Elderly with or at risk of Alzheimer's disease (review)

Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None vs: Standard care or placebo Outcome: Global cognition in stroke survivors Effet: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Population: Adult stroke survivors (20 trials + 14 observational)

Key Statistics

12

Études

3000

Participants

Mixed

C

Note

Referenced Papers

Journal of Alzheimer's … 2025 3 citations
American journal of … 2025
European geriatric medicine 2023 10 citations
Nutrients 2022 76 citations
Parkinsonism & related … 2015 100 citations
The British journal … 2015 62 citations
Plant foods for … 2013 155 citations
Orphanet journal of … 2011 158 citations
American family physician 2011
TheScientificWorldJournal 2009 38 citations
Clinica chimica acta; … 2006 134 citations
Archives of neurology 2002 354 citations
The Proceedings of … 2002 191 citations
Asia Pacific journal … 2002 24 citations
Current opinion in … 1998 30 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:
15 mg/day (RDA)
cognitivesupport:
400-800 IU/day

Limite supérieure : 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)

Posologies étudiées dans la recherche

Posologie Durée Effet N
None -- Positive 80488
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d -- Mixed --
Inflection at 29.65 g/day (DSST), 22.65 g/day (composite) -- Positive 2713
None -- Mixed --
None -- Positive --
None -- Mixed --
None -- Positive --
None -- Mixed --

Moment optimal de prise : With meals containing fat

Safety & Side Effects

Effets indésirables signalés

  • Increased bleeding risk at high doses
  • Nausea and diarrhea
  • Fatigue and weakness
  • Blurred vision

Interactions connues

  • Anticoagulants (increased bleeding risk)
  • Statins and niacin (may reduce HDL-raising effects)
  • Chemotherapy and radiation (may reduce efficacy)

Apport maximal tolérable : 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Vitamin E help with Age-Related Cognitive Decline?
Based on 12 studies with 3,000 participants, there is limited but promising evidence that Vitamin E may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Vitamin E should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 15 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin E?
Reported side effects may include Increased bleeding risk at high doses, Nausea and diarrhea, Fatigue and weakness, Blurred vision. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin E and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 3,000 total participants. The overall direction of effect is mixed.

Related Evidence

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.