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Vitamin E untuk Age-Related Cognitive Decline

C Bukti Bukti terbatas dari studi kecil, namun beberapa sinyal positif ada.

High-dose vitamin E may slow functional decline in moderate Alzheimer's disease (TEAM-AD trial). Results are mixed for cognitive decline prevention in healthy populations.

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Kesimpulan

High-dose vitamin E may slow functional decline in moderate Alzheimer's disease (TEAM-AD trial). Results are mixed for cognitive decline prevention in healthy populations.

Key Study Findings

Systematic Review n=80488
Vitamin E and cognitive function: A systematic review of clinical evidence.
Dose: None vs: None Outcome: cognitive function / cognitive impairment Efek: None None

Populasi: participants from 43 clinical studies (2012-2022)

Review
Cognitive Decline and Vitamins.
Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d vs: None Outcome: Cognitive decline in AD Efek: None None

Populasi: Alzheimer's disease patients

Observational Study n=2713 Open-label
Non-linear association between dietary fiber intake and cognitive function mediated by vitamin E: a cross-sectional …
Dose: Inflection at 29.65 g/day (DSST), 22.65 g/day (composite) vs: Cross-sectional fiber intake groups Outcome: Cognitive function composite z-scores (DSST, AFT, CERAD) Efek: β=0.18 per unit fiber below inflection <0.0001

Populasi: NHANES adults aged ≥60 years (2011-2014)

Review
The Role of Vitamins in Neurodegeneration: A Brief Review of Mechanisms, Clinical Evidence, and Therapeutic …
Dose: None vs: None Outcome: None Efek: None None

Populasi: Review of vitamins in neurodegeneration

Review
Bioactive compounds and dietary patterns in Alzheimer's disease.
Dose: None vs: None Outcome: AD progression and cognitive decline Efek: None None

Populasi: Elderly with or at risk of Alzheimer's disease (review)

Key Statistics

12

Studi

3000

Peserta

Mixed

C

Peringkat

Referenced Papers

Journal of Alzheimer's … 2025 3 sitasi
American journal of … 2025
European geriatric medicine 2023 10 sitasi
Nutrients 2022 76 sitasi
Plant foods for … 2013 155 sitasi
Orphanet journal of … 2011 158 sitasi
American family physician 2011
TheScientificWorldJournal 2009 38 sitasi
Clinica chimica acta; … 2006 134 sitasi
Archives of neurology 2002 354 sitasi
The Proceedings of … 2002 191 sitasi
Asia Pacific journal … 2002 24 sitasi
Current opinion in … 1998 30 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:
15 mg/day (RDA)
cognitivesupport:
400-800 IU/day

Batas atas: 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)

Dosis yang Diteliti dalam Penelitian

Dosis Durasi Efek N
None -- Positive 80488
None -- Mixed --
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d -- Mixed --
Inflection at 29.65 g/day (DSST), 22.65 g/day (composite) -- Positive 2713
None -- Mixed --
None -- Positive --
None -- Mixed --
>=112 mg/day vs <112 mg/day 270 weeks Positive 1550

Waktu terbaik diminum: With meals containing fat

Safety & Side Effects

Efek Samping yang Dilaporkan

  • Increased bleeding risk at high doses
  • Nausea and diarrhea
  • Fatigue and weakness
  • Blurred vision

Interaksi yang Diketahui

  • Anticoagulants (increased bleeding risk)
  • Statins and niacin (may reduce HDL-raising effects)
  • Chemotherapy and radiation (may reduce efficacy)

Asupan atas yang dapat ditoleransi: 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Vitamin E help with Age-Related Cognitive Decline?
Based on 12 studies with 3,000 participants, there is limited but promising evidence that Vitamin E may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Vitamin E should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 15 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin E?
Reported side effects may include Increased bleeding risk at high doses, Nausea and diarrhea, Fatigue and weakness, Blurred vision. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin E and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 3,000 total participants. The overall direction of effect is mixed.

References

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