Bacopa monnieri untuk Age-Related Cognitive Decline
B Bukti Setidaknya satu uji coba acak mendukung hal ini, dengan hasil yang sebagian besar konsisten.A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
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B
Kesimpulan
A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
Key Study Findings
Randomized Controlled Trial
6 weeks
Double-blind
Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in …
Dose: 120 mL twice daily for 45 days
vs: placebo
Outcome: telomerase activity and telomere length
Efek: None
None
Populasi: elderly participants with MoCA score >=24
Randomized Controlled Trial
n=76
12 weeks
Double-blind
Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients …
Dose: 300 mg/day standardized Bacopa monnieri extract
vs: placebo
Outcome: change in composite z score of memory at …
Efek: None
None
Populasi: patients with amnestic mild cognitive impairment, mean age 62.2 years, 88.3% men
Other
Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus …
Dose: 200 mg/kg body weight
vs: Rotenone-PD mice without BME
Outcome: Recognition memory and AMPA receptor expression
Efek: None
None
Populasi: Rotenone-induced Parkinson's disease mouse model
Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None
vs: None
Outcome: Cholinesterase inhibition and cognitive improvement
Efek: None
None
Populasi: In vivo animal models of AD
Other
A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via …
Dose: None
vs: Donepezil, Estradiol
Outcome: Neurotherapeutic activity via ESR1 and ACHE
Efek: None
None
Populasi: In silico AD modeling (systems biology)
Systematic Review
n=1861
The effect of plant active substances on cognitive function in healthy older adults: a systematic …
Dose: None
vs: Placebo or no intervention
Outcome: Cognitive function (learning, memory, executive)
Efek: Raisin SUCRA 95.1%; tart cherry 89.5% for memory
None
Populasi: Healthy older adults
Key Statistics
15
Studi
1200
Peserta
↑
Positive
B
Peringkat
Referenced Papers
Frontiers in medicine
2026
JMIR research protocols
2026
Brain sciences
2025
14 sitasi
Inflammopharmacology
2025
4 sitasi
Molecular neurobiology
2025
3 sitasi
The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of …
Systematic Review
Frontiers in pharmacology
2025
Current Alzheimer research
2024
10 sitasi
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 sitasi
Journal of complementary …
2022
3 sitasi
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
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2021
38 sitasi
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
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The Senior care …
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Alzheimer's research & …
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2019
103 sitasi
Pharmacological research
2018
67 sitasi
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2017
30 sitasi
Medical hypotheses
2016
6 sitasi
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2015
82 sitasi
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2014
54 sitasi
CNS drugs
2013
138 sitasi
Neurochemical research
2012
85 sitasi
Nutrition journal
2012
55 sitasi
Alternative medicine review …
1999
112 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 300-600 mg/day standardized to 50% bacosides
- memorysupport:
- 300 mg/day for minimum 8-12 weeks
Batas atas: Not established; well-tolerated up to 600 mg/day in trials
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| 120 mL twice daily for 45 days | 6 weeks | Neutral | -- |
| 300 mg/day standardized Bacopa monnieri extract | 12 weeks | Neutral | 76 |
| 200 mg/kg body weight | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 1861 |
| None | -- | Mixed | -- |
| None | 12 weeks | Positive | -- |
Waktu terbaik diminum: With meals; effects require 8-12 weeks of consistent use
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Gastrointestinal discomfort (nausea, cramping, diarrhea)
- ⚠ Dry mouth
- ⚠ Fatigue in some individuals
- ⚠ Mild sedation at higher doses
Interaksi yang Diketahui
- ● Thyroid medications (may increase thyroid hormone levels)
- ● Anticholinergic drugs (opposes cholinergic enhancement)
- ● Sedative medications (additive CNS depression)
- ● Calcium channel blockers (may enhance blood pressure lowering)
Asupan atas yang dapat ditoleransi: Not established; well-tolerated up to 600 mg/day in trials
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does Bacopa monnieri help with Age-Related Cognitive Decline?
Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Bacopa monnieri may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Bacopa monnieri should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 300-600 mg/day standardized to 50% bacosides. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bacopa monnieri?
Reported side effects may include Gastrointestinal discomfort (nausea, cramping, diarrhea), Dry mouth, Fatigue in some individuals, Mild sedation at higher doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bacopa monnieri and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Age-Related Cognitive Decline
Bacopa monnieri untuk kondisi lain
References
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- [2] Abhilasha Dwivedi et al.. JMIR Res Protoc. 2026. Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment … doi:10.2196/82891 PubMed
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- [17] Grace M McPhee et al.. Med Hypotheses. 2016. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. doi:10.1016/j.mehy.2016.09.002 PubMed
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