Bacopa monnieri 관련 노화성 인지 저하
B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
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B
결론
A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
Key Study Findings
Randomized Controlled Trial
6 weeks
Double-blind
Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in …
Dose: 120 mL twice daily for 45 days
vs: placebo
Outcome: telomerase activity and telomere length
효과: None
None
대상 집단: elderly participants with MoCA score >=24
Randomized Controlled Trial
n=76
12 weeks
Double-blind
Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients …
Dose: 300 mg/day standardized Bacopa monnieri extract
vs: placebo
Outcome: change in composite z score of memory at …
효과: None
None
대상 집단: patients with amnestic mild cognitive impairment, mean age 62.2 years, 88.3% men
Other
Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus …
Dose: 200 mg/kg body weight
vs: Rotenone-PD mice without BME
Outcome: Recognition memory and AMPA receptor expression
효과: None
None
대상 집단: Rotenone-induced Parkinson's disease mouse model
Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None
vs: None
Outcome: Cholinesterase inhibition and cognitive improvement
효과: None
None
대상 집단: In vivo animal models of AD
Other
A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via …
Dose: None
vs: Donepezil, Estradiol
Outcome: Neurotherapeutic activity via ESR1 and ACHE
효과: None
None
대상 집단: In silico AD modeling (systems biology)
Systematic Review
n=1861
The effect of plant active substances on cognitive function in healthy older adults: a systematic …
Dose: None
vs: Placebo or no intervention
Outcome: Cognitive function (learning, memory, executive)
효과: Raisin SUCRA 95.1%; tart cherry 89.5% for memory
None
대상 집단: Healthy older adults
Key Statistics
15
연구
1200
참여자
↑
Positive
B
등급
Referenced Papers
Frontiers in medicine
2026
JMIR research protocols
2026
Brain sciences
2025
14 인용
Inflammopharmacology
2025
4 인용
Molecular neurobiology
2025
3 인용
The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of …
Systematic Review
Frontiers in pharmacology
2025
Current Alzheimer research
2024
10 인용
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 인용
Journal of complementary …
2022
3 인용
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 인용
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
Journal of alternative …
2021
13 인용
The Senior care …
2021
2 인용
Alzheimer's research & …
2021
1 인용
Drug target insights
2019
103 인용
Pharmacological research
2018
67 인용
The journal of …
2017
30 인용
Medical hypotheses
2016
6 인용
Evidence-based complementary and …
2015
82 인용
Clinical drug investigation
2014
54 인용
CNS drugs
2013
138 인용
Neurochemical research
2012
85 인용
Nutrition journal
2012
55 인용
Alternative medicine review …
1999
112 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 300-600 mg/day standardized to 50% bacosides
- memorysupport:
- 300 mg/day for minimum 8-12 weeks
상한량: Not established; well-tolerated up to 600 mg/day in trials
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| 120 mL twice daily for 45 days | 6 weeks | Neutral | -- |
| 300 mg/day standardized Bacopa monnieri extract | 12 weeks | Neutral | 76 |
| 200 mg/kg body weight | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 1861 |
| None | -- | Mixed | -- |
| None | 12 weeks | Positive | -- |
권장 복용 시간: With meals; effects require 8-12 weeks of consistent use
Safety & Side Effects
보고된 부작용
- ⚠ Gastrointestinal discomfort (nausea, cramping, diarrhea)
- ⚠ Dry mouth
- ⚠ Fatigue in some individuals
- ⚠ Mild sedation at higher doses
알려진 상호작용
- ● Thyroid medications (may increase thyroid hormone levels)
- ● Anticholinergic drugs (opposes cholinergic enhancement)
- ● Sedative medications (additive CNS depression)
- ● Calcium channel blockers (may enhance blood pressure lowering)
일일 최대 섭취 허용량: Not established; well-tolerated up to 600 mg/day in trials
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Bacopa monnieri help with 노화성 인지 저하?
Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Bacopa monnieri may support 노화성 인지 저하 management. Our evidence grade is B (Good Evidence).
How much Bacopa monnieri should I take for 노화성 인지 저하?
Studies have used various dosages. A commonly studied range is 300-600 mg/day standardized to 50% bacosides. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bacopa monnieri?
Reported side effects may include Gastrointestinal discomfort (nausea, cramping, diarrhea), Dry mouth, Fatigue in some individuals, Mild sedation at higher doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bacopa monnieri and 노화성 인지 저하?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: 노화성 인지 저하
Bacopa monnieri 다른 건강 상태에 대한 근거
References
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- [2] Abhilasha Dwivedi et al.. JMIR Res Protoc. 2026. Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment … doi:10.2196/82891 PubMed
- [3] Maryam N ALNasser et al.. Brain Sci. 2025. Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review. doi:10.3390/brainsci15020215 PubMed
- [4] Mayank Roy Chowdhury et al.. Inflammopharmacology. 2025. A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via estrogen signaling and cholinergic modulation. doi:10.1007/s10787-025-01872-1 PubMed
- [5] Vartika Gupta et al.. Mol Neurobiol. 2025. Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus Are Associated with Recognition Memory … doi:10.1007/s12035-024-04392-1 PubMed
- [6] Xueyan Feng et al.. Front Pharmacol. 2025. The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of … doi:10.3389/fphar.2025.1672171 PubMed
- [7] Debasis Sen et al.. Curr Alzheimer Res. 2024. Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration. doi:10.2174/0115672050309057240404075003 PubMed
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- [12] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
- [13] Andrea Brioschi Guevara et al.. Alzheimers Res Ther. 2021. Protocols for cognitive enhancement. A user manual for Brain Health Services-part 5 of 6. doi:10.1186/s13195-021-00844-1 PubMed
- [14] Aimi Syamima Abdul Manap et al.. Drug Target Insights. 2019. Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical … doi:10.1177/1177392819866412 PubMed
- [15] Arrigo F G Cicero et al.. Pharmacol Res. 2018. Botanicals and phytochemicals active on cognitive decline: The clinical evidence. doi:10.1016/j.phrs.2017.12.029 PubMed
- [16] A F Cicero et al.. J Prev Alzheimers Dis. 2017. Short-Term Impact of a Combined Nutraceutical on Cognitive Function, Perceived Stress and Depression in Young Elderly with Cognitive Impairment: A … doi:10.14283/jpad.2016.10 PubMed
- [17] Grace M McPhee et al.. Med Hypotheses. 2016. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. doi:10.1016/j.mehy.2016.09.002 PubMed
- [18] Tamara Simpson et al.. Evid Based Complement Alternat Med. 2015. Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. doi:10.1155/2015/615384 PubMed
- [19] Ananya Sadhu et al.. Clin Drug Investig. 2014. Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product. doi:10.1007/s40261-014-0235-9 PubMed
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- [21] Neetu Saini et al.. Neurochem Res. 2012. Neuroprotective effects of Bacopa monnieri in experimental model of dementia. doi:10.1007/s11064-012-0811-4 PubMed
- [22] Con K Stough et al.. Nutr J. 2012. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning … doi:10.1186/1475-2891-11-11 PubMed
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