Gotu Kola 관련 노화성 인지 저하
D 연구 예비 연구(실험실 연구, 증례 보고)만 존재합니다.A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.
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D
결론
A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.
Key Study Findings
Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None
vs: None
Outcome: Cholinesterase inhibition and cognitive improvement
효과: None
None
대상 집단: In vivo animal models of AD
Controlled Clinical Trial
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day
vs: Control chow
Outcome: Sleep quality and quantity (EEG/EMG)
효과: None
None
대상 집단: 18-month-old male and female C57BL6/J mice
In Vitro
In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and …
Dose: None
vs: H2O2-induced oxidative stress
Outcome: Neuroprotection and cognitive decline biomarkers
효과: BDNF ~2.3-fold, NGF ~1.9-fold vs H2O2
None
대상 집단: 3D intestinal model and neuronal/astrocytic co-culture
Other
Centella asiatica improves sleep quality and quantity in aged mice.
Dose: 1000 mg/kg/day
vs: Control chow
Outcome: Sleep composition (REM/NREM duration, arousals)
효과: None
None
대상 집단: Aged (18-month) C57BL6/J mice
Review
Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments.
Dose: None
vs: None
Outcome: DM and AD symptom management
효과: None
None
대상 집단: Patients with diabetes and Alzheimer's disease (review)
Other
Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.
Dose: None
vs: None
Outcome: AChE and BACE1 inhibition for Alzheimer's
효과: None
None
대상 집단: In silico AD drug discovery (820 metabolites screened)
Key Statistics
4
연구
200
참여자
↑
Positive
D
등급
Referenced Papers
Brain sciences
2025
14 인용
Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments.
Review
Journal of ethnopharmacology
2025
6 인용
Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants.
Other
PloS one
2025
3 인용
Foods (Basel, Switzerland)
2025
3 인용
Computers in biology …
2025
2 인용
bioRxiv : the …
2025
1 인용
Sleep advances : …
2025
Frontiers in aging
2024
11 인용
Journal of ethnopharmacology
2024
4 인용
Food science & …
2024
3 인용
Journal of Alzheimer's …
2024
3 인용
Journal of Alzheimer's …
2024
2 인용
bioRxiv : the …
2024
Tzu chi medical …
2023
6 인용
Journal of pharmacological …
2022
18 인용
Biomolecules
2021
161 인용
Neurobiology of aging
2021
29 인용
Frontiers in nutrition
2021
13 인용
Nutrients
2020
55 인용
Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions.
Other
Drug metabolism and …
2020
CNS drugs
2013
138 인용
Phytotherapy research : …
2007
256 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 500-1,000 mg/day standardized extract
- cognitivesupport:
- 750 mg/day
상한량: Not established; hepatotoxicity reported rarely at very high doses
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 1000 mg/kg/day | -- | Positive | -- |
| None | -- | Positive | -- |
| 1000 mg/kg/day | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1 μg/mL | -- | Positive | -- |
권장 복용 시간: With meals
Safety & Side Effects
보고된 부작용
- ⚠ Skin irritation (topical)
- ⚠ Headache
- ⚠ Gastrointestinal discomfort
- ⚠ Drowsiness
- ⚠ Rare: liver toxicity at very high doses
알려진 상호작용
- ● Hepatotoxic drugs (additive liver stress)
- ● Sedative medications (additive CNS depression)
- ● Cholesterol-lowering drugs (theoretical interaction)
일일 최대 섭취 허용량: Not established; hepatotoxicity reported rarely at very high doses
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Gotu Kola help with 노화성 인지 저하?
Based on 4 studies with 200 participants, there is preliminary evidence that needs more research that Gotu Kola may support 노화성 인지 저하 management. Our evidence grade is D (Very Early Research).
How much Gotu Kola should I take for 노화성 인지 저하?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day standardized extract. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Gotu Kola?
Reported side effects may include Skin irritation (topical), Headache, Gastrointestinal discomfort, Drowsiness. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Gotu Kola and 노화성 인지 저하?
We rate the evidence as Grade D (Very Early Research). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
Related Evidence
References
- [1] Maryam N ALNasser et al.. Brain Sci. 2025. Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review. doi:10.3390/brainsci15020215 PubMed
- [2] Sandesh Kumar Pattanaik et al.. J Ethnopharmacol. 2025. Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatments. doi:10.1016/j.jep.2025.120092 PubMed
- [3] Mohibullah Shah et al.. PLoS One. 2025. Computer-aided discovery of dual-target compounds for Alzheimer's from ayurvedic medicinal plants. doi:10.1371/journal.pone.0325441 PubMed
- [4] Rebecca Galla et al.. Foods. 2025. In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide. doi:10.3390/foods14152678 PubMed
- [5] Miski Aghnia Khairinisa et al.. Comput Biol Med. 2025. Bioactive potential of Centella asiatica leaf extract in acetylcholinesterase (AChE) inhibition: Insights from multiple ligand mapping. doi:10.1016/j.compbiomed.2025.110970 PubMed
- [6] Laura Dovek et al.. bioRxiv. 2025. Centella asiatica improves sleep quality and quantity in aged mice. doi:10.1101/2025.02.01.636070 PubMed
- [7] Laura Dovek et al.. Sleep Adv. 2025. Centella asiatica improves sleep quality and quantity in aged mice. doi:10.1093/sleepadvances/zpaf060 PubMed
- [8] Nora E Gray et al.. Front Aging. 2024. Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of … doi:10.3389/fragi.2024.1357922 PubMed
- [9] Zeba Firdaus et al.. J Ethnopharmacol. 2024. Centella asiatica improves memory and executive function in middle-aged rats by controlling oxidative stress and cholinergic transmission. doi:10.1016/j.jep.2024.117888 PubMed
- [10] Shuge Gui et al.. Food Sci Nutr. 2024. A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation. doi:10.1002/fsn3.4045 PubMed
- [11] Takaya Suganuma et al.. J Alzheimers Dis. 2024. Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden. doi:10.3233/JAD-240033 PubMed
- [12] Donald G Matthews et al.. J Alzheimers Dis Rep. 2024. Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice. doi:10.1177/25424823241296740 PubMed
- [13] Nora E Gray et al.. bioRxiv. 2024. Amelioration of age-related cognitive decline and anxiety in mice by Centella asiatica extract varies by sex, dose and mode of … doi:10.1101/2024.01.23.576700 PubMed
- [14] Peeraporn Varinthra et al.. Tzu Chi Med J. 2023. Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer's disease. doi:10.4103/tcmj.tcmj_139_22 PubMed
- [15] Honoka Fujimori et al.. J Pharmacol Sci. 2022. The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment. doi:10.1016/j.jphs.2021.11.001 PubMed
- [16] Julie Gregory et al.. Biomolecules. 2021. Neuroprotective Herbs for the Management of Alzheimer's Disease. doi:10.3390/biom11040543 PubMed
- [17] Jonathan A Zweig et al.. Neurobiol Aging. 2021. Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica … doi:10.1016/j.neurobiolaging.2020.11.019 PubMed
- [18] Kirsten M Wright et al.. Front Nutr. 2021. Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges. doi:10.3389/fnut.2021.799137 PubMed
- [19] Donald G Matthews et al.. Nutrients. 2020. Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer's Disease Model Mice. doi:10.3390/nu12113488 PubMed
- [20] Kirsten M Wright et al.. Drug Metab Dispos. 2020. Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions. doi:10.1124/dmd.120.090860 PubMed
- [21] Jerome Sarris et al.. CNS Drugs. 2013. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. doi:10.1007/s40263-013-0059-9 PubMed
- [22] Pulok K Mukherjee et al.. Phytother Res. 2007. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. doi:10.1002/ptr.2224 PubMed
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