Vitamin B12 관련 노화성 인지 저하
B 근거 적어도 하나의 무작위 시험이 이를 지지하며, 대체로 일관된 결과를 보입니다.Combined B12 and folate supplementation slowed brain atrophy rate in MCI patients compared to placebo. Homocysteine reduction appears to be the primary mechanism linking B12 status to cognitive preservation.
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B
결론
Combined B12 and folate supplementation slowed brain atrophy rate in MCI patients compared to placebo. Homocysteine reduction appears to be the primary mechanism linking B12 status to cognitive preservation.
Key Study Findings
Review
Vitamin B12 deficiency among older adults and its associations with geriatric syndromes.
Dose: None
vs: None
Outcome: None
효과: None
None
대상 집단: older adults with vitamin B12 deficiency and geriatric syndromes
Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None
vs: Standard care or placebo
Outcome: Global cognition in stroke survivors
효과: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins)
0.009 (protein); 0.02 (B-vit)
대상 집단: Adult stroke survivors (20 trials + 14 observational)
Controlled Clinical Trial
32 weeks
Vitamin B12 supplementation attenuates endoplasmic reticulum stress and neuronal cell death in the cerebral cortex …
Dose: 50 ug/kg diet vs 25 ug/kg diet
vs: HFHS diet without extra B12
Outcome: ER stress and neuronal cell death in cerebral …
효과: None
None
대상 집단: Male C57BL/6J mice on high-fat high-sucrose diet
Other
Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian …
Dose: None
vs: None
Outcome: Effect of serum B12 on psychiatric disorders (MR)
효과: OR 1.02 [1.00-1.04] for depression per SD increase
0.11 (depression); 0.39 (educa
대상 집단: General population (Mendelian randomization, large GWAS)
Systematic Review
Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review.
Dose: None
vs: None
Outcome: Neurological health outcomes
효과: None
None
대상 집단: None
Review
Unlocking the cellular mystery: how proton pump inhibitors may alter the dementia landscape.
Dose: None
vs: None
Outcome: Dementia risk with PPI use
효과: None
None
대상 집단: PPI users and dementia risk (review)
Key Statistics
12
연구
2800
참여자
↑
Positive
B
등급
Referenced Papers
Current opinion in …
2026
Nutrients
2025
22 인용
Brain research
2025
6 인용
Cureus
2025
4 인용
Communications medicine
2025
3 인용
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Meta-Analysis
Advances in nutrition …
2025
1 인용
Nutrition (Burbank, Los …
2025
Journal of clinical …
2024
29 인용
Current Alzheimer research
2024
14 인용
Science translational medicine
2024
12 인용
Food and nutrition …
2024
2 인용
Homocysteine levels, genetic background, and cognitive impairment in Parkinson's disease.
Meta-Analysis
Journal of neurology
2023
34 인용
Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment.
Review
The Proceedings of …
2023
27 인용
Annals of neurology
2023
15 인용
Nutricion hospitalaria
2023
13 인용
Molecular and cellular …
2023
8 인용
Clinical nutrition ESPEN
2023
5 인용
Vitamin Supplementation and Dementia: A Systematic Review.
Systematic Review
Nutrients
2022
76 인용
Vitamins and hormones
2022
28 인용
Current nutrition reports
2022
25 인용
International journal of …
2022
23 인용
The Journal of …
2022
13 인용
Cognitive function and vitamin B12 and D among community-dwelling elders: A cross-sectional study.
Other
Clinical nutrition ESPEN
2022
12 인용
Cureus
2022
6 인용
Cureus
2020
65 인용
Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.
Meta-Analysis
Journal of Alzheimer's …
2020
34 인용
Association between Vitamin B12 levels and cognitive function in the elderly Korean population.
Observational
Medicine
2020
29 인용
Systematic reviews
2020
29 인용
Cureus
2020
5 인용
Revue neurologique
2019
361 인용
Journal of Alzheimer's …
2018
281 인용
Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Systematic Review
Annals of internal …
2018
119 인용
Nutrients
2018
30 인용
Annals of surgical …
2018
22 인용
American family physician
2017
282 인용
Annual review of …
2016
432 인용
Nutrition research (New …
2016
131 인용
Is Metformin-Induced Vitamin B12 Deficiency Responsible for Cognitive Decline in Type 2 Diabetes?
Other
Indian journal of …
2016
23 인용
Journal of biomedical …
2016
Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis.
Meta-Analysis
Climacteric : the …
2015
92 인용
Annals of Indian …
2015
1 인용
Neuroscience and biobehavioral …
2014
148 인용
Nutrition reviews
2014
25 인용
Nutrition journal
2013
26 인용
Ontario health technology …
2013
Vitamin B₁₂ status, cognitive decline and dementia: a systematic review of prospective cohort studies.
Systematic Review
The British journal …
2012
87 인용
Late-adult onset Leigh syndrome.
Case Report
Journal of clinical …
2012
54 인용
Experimental aging research
2010
21 인용
The Practitioner
2010
Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.
Systematic Review
International journal of …
2009
125 인용
Neurology
2009
124 인용
Epidemiology (Cambridge, Mass.)
2006
49 인용
Journal of Alzheimer's …
2006
37 인용
Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons.
Other
Archives of neurology
2005
263 인용
Neurology India
2004
71 인용
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 인용
Current opinion in …
1998
30 인용
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
일반적으로 사용되는 용량
- general:
- 2.4 mcg/day (RDA)
- deficiency:
- 1,000-2,000 mcg/day
- cognitivesupport:
- 500-1,000 mcg/day
상한량: No established UL (water-soluble, low toxicity)
연구에서 사용된 용량
| 용량 | 기간 | 효과 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| 50 ug/kg diet vs 25 ug/kg diet | 32 weeks | Positive | -- |
| None | -- | Neutral | -- |
| None | -- | Mixed | -- |
| None | -- | Negative | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
권장 복용 시간: Morning, on empty stomach for better absorption (sublingual)
Safety & Side Effects
보고된 부작용
- ⚠ Generally very well-tolerated
- ⚠ Rare: acne-like eruptions at high doses
- ⚠ Injection site reactions (injectable form)
알려진 상호작용
- ● Metformin (reduces B12 absorption)
- ● Proton pump inhibitors (reduce B12 absorption)
- ● Colchicine (reduces B12 absorption)
일일 최대 섭취 허용량: No established UL (water-soluble, low toxicity)
건강기능식품을 복용하기 전에 반드시 의료 전문가와 상담하십시오.
Frequently Asked Questions
Does Vitamin B12 help with 노화성 인지 저하?
Based on 12 studies with 2,800 participants, there is moderate evidence from clinical studies that Vitamin B12 may support 노화성 인지 저하 management. Our evidence grade is B (Good Evidence).
How much Vitamin B12 should I take for 노화성 인지 저하?
Studies have used various dosages. A commonly studied range is 2.4 mcg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin B12?
Reported side effects may include Generally very well-tolerated, Rare: acne-like eruptions at high doses, Injection site reactions (injectable form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin B12 and 노화성 인지 저하?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,800 total participants. The overall direction of effect is positive.
Related Evidence
관련 다른 성분: 노화성 인지 저하
Vitamin B12 다른 건강 상태에 대한 근거
References
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