Gotu Kola for Age-Related Cognitive Decline
DA traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.
The Bottom Line
A traditional Ayurvedic brain tonic with emerging evidence for neuroprotective effects. Triterpene saponins promote nerve growth and dendritic arborization, but clinical evidence remains limited.
Key Study Findings
Population: In vivo animal models of AD
Population: 18-month-old male and female C57BL6/J mice
Population: 3D intestinal model and neuronal/astrocytic co-culture
Population: Aged (18-month) C57BL6/J mice
Population: Patients with diabetes and Alzheimer's disease (review)
Population: In silico AD drug discovery (820 metabolites screened)
Key Statistics
4
Studies
200
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 500-1,000 mg/day standardized extract
- cognitivesupport:
- 750 mg/day
Upper limit: Not established; hepatotoxicity reported rarely at very high doses
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 1000 mg/kg/day | -- | Positive | -- |
| None | -- | Positive | -- |
| 1000 mg/kg/day | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 1 μg/mL | -- | Positive | -- |
Best taken: With meals
Safety & Side Effects
Reported Side Effects
- ⚠ Skin irritation (topical)
- ⚠ Headache
- ⚠ Gastrointestinal discomfort
- ⚠ Drowsiness
- ⚠ Rare: liver toxicity at very high doses
Known Interactions
- ● Hepatotoxic drugs (additive liver stress)
- ● Sedative medications (additive CNS depression)
- ● Cholesterol-lowering drugs (theoretical interaction)
Tolerable upper intake: Not established; hepatotoxicity reported rarely at very high doses
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Gotu Kola help with Age-Related Cognitive Decline?
How much Gotu Kola should I take for Age-Related Cognitive Decline?
Are there side effects of Gotu Kola?
How strong is the evidence for Gotu Kola and Age-Related Cognitive Decline?
Related Evidence
Other ingredients for Age-Related Cognitive Decline
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.