Phosphatidylserine for Age-Related Cognitive Decline
BThe FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.
The Bottom Line
The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.
Key Study Findings
Population: cerebral FURIN-deficient mice
Population: male Sprague-Dawley rats with scopolamine-induced memory impairment
Population: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)
Population: Alzheimer's disease patients
Population: HFD-induced obese male C57BL/6 mice
Population: Mouse model
Key Statistics
16
Studies
1100
Participants
Positive
Grade
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Commonly Used Dosages
- general:
- 100 mg/day
- cognitivesupport:
- 100-300 mg/day
Upper limit: Well-tolerated up to 600 mg/day
Dosages Studied in Research
| Dosage | Duration | Effect | N |
|---|---|---|---|
| None | -- | Negative | -- |
| 50, 100, or 200 mg/kg/day | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d | -- | Mixed | -- |
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Positive | -- |
| 1 μg/mL | -- | Positive | -- |
| None | 72 weeks | Positive | -- |
Best taken: With meals for better absorption
Safety & Side Effects
Reported Side Effects
- ⚠ Mild gastrointestinal discomfort
- ⚠ Insomnia at high doses
- ⚠ Rare allergic reactions (soy-derived forms)
Known Interactions
- ● Anticholinergic medications (may reduce PS effectiveness)
- ● Blood thinners (theoretical interaction)
- ● Cholinesterase inhibitors (additive cholinergic effects)
Tolerable upper intake: Well-tolerated up to 600 mg/day
Always consult your healthcare provider before starting any supplement.
Frequently Asked Questions
Does Phosphatidylserine help with Age-Related Cognitive Decline?
How much Phosphatidylserine should I take for Age-Related Cognitive Decline?
Are there side effects of Phosphatidylserine?
How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?
Related Evidence
Other ingredients for Age-Related Cognitive Decline
Phosphatidylserine for other conditions
FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.