Skip to main content
BrainCited

Phosphatidylserine для Age-Related Cognitive Decline

B Доказательства По меньшей мере одно рандомизированное исследование подтверждает это, с в целом согласованными результатами.

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'braincited.com'; const params = 'ingredient\u003Dphosphatidylserine\u0026condition\u003Dcognitive\u002Ddecline'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    

Widget powered by . Free, no account required.

B

Итог

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

Key Study Findings

Other
Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.
Dose: None или: None Outcome: astrocytic lipophagy and cognitive function Эффект: None None

Популяция: cerebral FURIN-deficient mice

Other 4 weeks
Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell …
Dose: 50, 100, or 200 mg/kg/day или: phosphatidylserine 50 mg/kg/day (positive control) Outcome: cognitive performance in scopolamine-induced memory impairment Эффект: None None

Популяция: male Sprague-Dawley rats with scopolamine-induced memory impairment

In Vitro
Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.
Dose: None или: None Outcome: Age-dependent brain lipid changes Эффект: None None

Популяция: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)

Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d или: None Outcome: Cognitive decline in AD Эффект: None None

Популяция: Alzheimer's disease patients

Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice или: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) Эффект: None None

Популяция: HFD-induced obese male C57BL/6 mice

Other
Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.
Dose: None или: None Outcome: Cognitive function Эффект: None None

Популяция: Mouse model

Key Statistics

16

Исследования

1100

Участники

Positive

B

Оценка

Referenced Papers

Journal of proteome … 2025 8 цитирований
The Senior care … 2021 2 цитирований
Frontiers in psychology 2018 13 цитирований
Nutrition (Burbank, Los … 2015 149 цитирований
Current treatment options … 2011 6 цитирований
Sports medicine (Auckland, … 2006 42 цитирований
Nutritional neuroscience 2002 46 цитирований
Alternative medicine review … 1999 112 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
100 mg/day
cognitivesupport:
100-300 mg/day

Верхний предел: Well-tolerated up to 600 mg/day

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Negative --
50, 100, or 200 mg/kg/day 4 weeks Positive --
None -- Mixed --
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d -- Mixed --
50 mg/kg lycopene in mice -- Positive --
None -- Positive --
1 μg/mL -- Positive --
None 72 weeks Positive --

Лучшее время приёма: With meals for better absorption

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Mild gastrointestinal discomfort
  • Insomnia at high doses
  • Rare allergic reactions (soy-derived forms)

Известные взаимодействия

  • Anticholinergic medications (may reduce PS effectiveness)
  • Blood thinners (theoretical interaction)
  • Cholinesterase inhibitors (additive cholinergic effects)

Допустимый верхний уровень потребления: Well-tolerated up to 600 mg/day

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Phosphatidylserine help with Age-Related Cognitive Decline?
Based on 16 studies with 1,100 participants, there is moderate evidence from clinical studies that Phosphatidylserine may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Phosphatidylserine should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Phosphatidylserine?
Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 1,100 total participants. The overall direction of effect is positive.

Phosphatidylserine для других состояний

References

  1. [1] Xiao-Yong Xie et al.. Autophagy. 2026. Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. doi:10.1080/15548627.2025.2601039 PubMed
  2. [2] Kang-Il Oh et al.. Int J Mol Sci. 2026. Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell Death and Scopolamine-Induced Memory Impairment. doi:10.3390/ijms27052508 PubMed
  3. [3] Paola Gualtieri et al.. Nutrients. 2025. Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease. doi:10.3390/nu17050922 PubMed
  4. [4] Punyatoya Panda et al.. J Proteome Res. 2025. Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. doi:10.1021/acs.jproteome.4c00688 PubMed
  5. [5] Yuqing Wu et al.. Clin Nutr. 2025. Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. doi:10.1016/j.clnu.2025.06.005 PubMed
  6. [6] Wenxin Qi et al.. Int J Biol Sci. 2024. Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline. doi:10.7150/ijbs.103225 PubMed
  7. [7] Shuge Gui et al.. Food Sci Nutr. 2024. A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation. doi:10.1002/fsn3.4045 PubMed
  8. [8] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
  9. [9] Ying-Cai Zhao et al.. Lipids Health Dis. 2020. Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat … doi:10.1186/s12944-020-01253-3 PubMed
  10. [10] Syena Sarrafpour et al.. Int J Environ Res Public Health. 2019. Lipid Metabolism in Late-Onset Alzheimer's Disease Differs from Patients Presenting with Other Dementia Phenotypes. doi:10.3390/ijerph16111995 PubMed
  11. [11] Paul Fairbairn et al.. Prostaglandins Leukot Essent Fatty Acids. 2019. Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function … doi:10.1016/j.plefa.2019.04.001 PubMed
  12. [12] Benjamin Zealley et al.. Rejuvenation Res. 2019. Commentary on Some Recent Theses Relevant to Combating Aging: October 2019. doi:10.1089/rej.2019.2270 PubMed
  13. [13] Durga Chapagain et al.. Front Psychol. 2018. Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. doi:10.3389/fpsyg.2018.02217 PubMed
  14. [14] Philippa A Jackson et al.. Nutrients. 2016. DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … doi:10.3390/nu8020086 PubMed
  15. [15] Michael J Glade et al.. Nutrition. 2015. Phosphatidylserine and the human brain. doi:10.1016/j.nut.2014.10.014 PubMed
  16. [16] Shengyuan Wang et al.. PLoS One. 2015. Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease. doi:10.1371/journal.pone.0143135 PubMed
  17. [17] Noemí Fabelo et al.. Mol Med. 2011. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. doi:10.2119/molmed.2011.00119 PubMed
  18. [18] Michael J Serby et al.. Curr Treat Options Neurol. 2011. Treatment of memory loss with herbal remedies. doi:10.1007/s11940-011-0135-8 PubMed
  19. [19] Nataliya A Babenko et al.. Exp Gerontol. 2010. Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats. doi:10.1016/j.exger.2010.02.010 PubMed
  20. [20] James Suchy et al.. Nutr Res. 2009. Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … doi:10.1016/j.nutres.2008.11.004 PubMed
  21. [21] Patrizia Formichi et al.. J Cell Physiol. 2009. Apoptosis in CADASIL: an in vitro study of lymphocytes and fibroblasts from a cohort of Italian patients. doi:10.1002/jcp.21695 PubMed
  22. [22] Joseph A Araujo et al.. Can Vet J. 2008. Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. PubMed
  23. [23] Parris M Kidd. Altern Med Rev. 2008. Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. PubMed
  24. [24] Parris M Kidd. Altern Med Rev. 2007. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. PubMed
  25. [25] Michael Kingsley. Sports Med. 2006. Effects of phosphatidylserine supplementation on exercising humans. doi:10.2165/00007256-200636080-00003 PubMed
  26. [26] B L Jorissen et al.. Nutr Neurosci. 2002. Safety of soy-derived phosphatidylserine in elderly people. doi:10.1080/1028415021000033802 PubMed
  27. [27] B L Jorissen et al.. Nutr Neurosci. 2001. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. doi:10.1080/1028415x.2001.11747356 PubMed
  28. [28] P M Kidd. Altern Med Rev. 1999. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. PubMed
  29. [29] T Cenacchi et al.. Aging (Milano). 1993. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. doi:10.1007/BF03324139 PubMed

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.