Phosphatidylserine per Age-Related Cognitive Decline
B Evidenze Almeno un trial randomizzato lo supporta, con risultati per lo più coerenti.The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.
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B
In sintesi
The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.
Key Study Findings
Other
Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.
Dose: None
vs: None
Outcome: astrocytic lipophagy and cognitive function
Effetto: None
None
Popolazione: cerebral FURIN-deficient mice
Other
4 weeks
Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell …
Dose: 50, 100, or 200 mg/kg/day
vs: phosphatidylserine 50 mg/kg/day (positive control)
Outcome: cognitive performance in scopolamine-induced memory impairment
Effetto: None
None
Popolazione: male Sprague-Dawley rats with scopolamine-induced memory impairment
In Vitro
Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.
Dose: None
vs: None
Outcome: Age-dependent brain lipid changes
Effetto: None
None
Popolazione: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)
Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d
vs: None
Outcome: Cognitive decline in AD
Effetto: None
None
Popolazione: Alzheimer's disease patients
Other
Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …
Dose: 50 mg/kg lycopene in mice
vs: HFD control mice
Outcome: Cognitive function (Y-maze, MWM, novel object recognition)
Effetto: None
None
Popolazione: HFD-induced obese male C57BL/6 mice
Other
Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.
Dose: None
vs: None
Outcome: Cognitive function
Effetto: None
None
Popolazione: Mouse model
Key Statistics
16
Studi
1100
Partecipanti
↑
Positive
B
Grado
Referenced Papers
Autophagy
2026
1 citazioni
International journal of …
2026
Nutrients
2025
9 citazioni
Journal of proteome …
2025
8 citazioni
Clinical nutrition (Edinburgh, …
2025
1 citazioni
International journal of …
2024
6 citazioni
Food science & …
2024
3 citazioni
The Senior care …
2021
2 citazioni
Lipids in health …
2020
International journal of …
2019
12 citazioni
Prostaglandins, leukotrienes, and …
2019
5 citazioni
Rejuvenation research
2019
Frontiers in psychology
2018
13 citazioni
Nutrients
2016
53 citazioni
Nutrition (Burbank, Los …
2015
149 citazioni
PloS one
2015
11 citazioni
Molecular medicine (Cambridge, …
2011
356 citazioni
Current treatment options …
2011
6 citazioni
Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats.
Other
Experimental gerontology
2010
33 citazioni
Nutrition research (New …
2009
65 citazioni
Journal of cellular …
2009
31 citazioni
The Canadian veterinary …
2008
Alternative medicine review …
2008
Alternative medicine review …
2007
Sports medicine (Auckland, …
2006
42 citazioni
Nutritional neuroscience
2002
46 citazioni
The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment.
CCT
Nutritional neuroscience
2001
66 citazioni
Alternative medicine review …
1999
112 citazioni
Aging (Milan, Italy)
1993
137 citazioni
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosaggi di uso comune
- general:
- 100 mg/day
- cognitivesupport:
- 100-300 mg/day
Limite massimo: Well-tolerated up to 600 mg/day
Dosaggi studiati nella ricerca
| Dosaggio | Durata | Effetto | N |
|---|---|---|---|
| None | -- | Negative | -- |
| 50, 100, or 200 mg/kg/day | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d | -- | Mixed | -- |
| 50 mg/kg lycopene in mice | -- | Positive | -- |
| None | -- | Positive | -- |
| 1 μg/mL | -- | Positive | -- |
| None | 72 weeks | Positive | -- |
Momento migliore per l'assunzione: With meals for better absorption
Safety & Side Effects
Effetti collaterali segnalati
- ⚠ Mild gastrointestinal discomfort
- ⚠ Insomnia at high doses
- ⚠ Rare allergic reactions (soy-derived forms)
Interazioni note
- ● Anticholinergic medications (may reduce PS effectiveness)
- ● Blood thinners (theoretical interaction)
- ● Cholinesterase inhibitors (additive cholinergic effects)
Livello di assunzione massimo tollerabile: Well-tolerated up to 600 mg/day
Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.
Frequently Asked Questions
Does Phosphatidylserine help with Age-Related Cognitive Decline?
Based on 16 studies with 1,100 participants, there is moderate evidence from clinical studies that Phosphatidylserine may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Phosphatidylserine should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Phosphatidylserine?
Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 1,100 total participants. The overall direction of effect is positive.
Related Evidence
Altri ingredienti per Age-Related Cognitive Decline
Phosphatidylserine per altre condizioni
References
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- [2] Kang-Il Oh et al.. Int J Mol Sci. 2026. Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell Death and Scopolamine-Induced Memory Impairment. doi:10.3390/ijms27052508 PubMed
- [3] Paola Gualtieri et al.. Nutrients. 2025. Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease. doi:10.3390/nu17050922 PubMed
- [4] Punyatoya Panda et al.. J Proteome Res. 2025. Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. doi:10.1021/acs.jproteome.4c00688 PubMed
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- [12] Benjamin Zealley et al.. Rejuvenation Res. 2019. Commentary on Some Recent Theses Relevant to Combating Aging: October 2019. doi:10.1089/rej.2019.2270 PubMed
- [13] Durga Chapagain et al.. Front Psychol. 2018. Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. doi:10.3389/fpsyg.2018.02217 PubMed
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- [20] James Suchy et al.. Nutr Res. 2009. Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … doi:10.1016/j.nutres.2008.11.004 PubMed
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- [22] Joseph A Araujo et al.. Can Vet J. 2008. Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. PubMed
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- [27] B L Jorissen et al.. Nutr Neurosci. 2001. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. doi:10.1080/1028415x.2001.11747356 PubMed
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