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Phosphatidylserine for Stress-Induced Cognitive Decline

C

Research suggests phosphatidylserine may support cortisol regulation and help buffer stress-induced cognitive impairment through its role in neuronal membrane function.

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            C

        

        

            
The Bottom Line

            
            
Research suggests phosphatidylserine may support cortisol regulation and help buffer stress-induced cognitive impairment through its role in neuronal membrane function.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Other
                
                
                
                72 weeks
                
                
            

            
                Online Promotion of "Brain Health" Supplements.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: None

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
6

        
Studies

    

    

        
400

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Online Promotion of "Brain Health" Supplements.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        The Senior care …
                        2021
                        
                        2 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
100 mg/day

                    

                    
                    

                        
cognitivesupport:

                        
100-300 mg/day

                    

                    
                

                
                

                    Upper limit: Well-tolerated up to 600 mg/day
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                72 weeks
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With meals for better absorption
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            Rare allergic reactions (soy-derived forms)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Anticholinergic medications (may reduce PS effectiveness)
                        
    • 
                        
                        
  • 
                            ●
                            Blood thinners (theoretical interaction)
                        
    • 
                        
                        
  • 
                            ●
                            Cholinesterase inhibitors (additive cholinergic effects)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Well-tolerated up to 600 mg/day
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Phosphatidylserine help with Stress-Induced Cognitive Decline?
            
        
        

            Based on 6 studies with 400 participants, there is limited but promising evidence that Phosphatidylserine may support Stress-Induced Cognitive Decline management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Phosphatidylserine should I take for Stress-Induced Cognitive Decline?
            
        
        

            Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Phosphatidylserine?
            
        
        

            Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Phosphatidylserine and Stress-Induced Cognitive Decline?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Other ingredients for Stress-Induced Cognitive Decline

                    

                        
                        
                            Ashwagandha
                            B

                        
                        
                        
                            Rhodiola rosea
                            B

                        
                        
                    

                

                

                
                
                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.