Bacopa monnieri für Age-Related Cognitive Decline
B Evidenz Mindestens eine randomisierte Studie unterstützt dies, mit überwiegend konsistenten Ergebnissen.A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
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B
Fazit
A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
Key Study Findings
Randomized Controlled Trial
6 weeks
Double-blind
Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in …
Dose: 120 mL twice daily for 45 days
vs.: placebo
Outcome: telomerase activity and telomere length
Wirkung: None
None
Population: elderly participants with MoCA score >=24
Randomized Controlled Trial
n=76
12 weeks
Double-blind
Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients …
Dose: 300 mg/day standardized Bacopa monnieri extract
vs.: placebo
Outcome: change in composite z score of memory at …
Wirkung: None
None
Population: patients with amnestic mild cognitive impairment, mean age 62.2 years, 88.3% men
Other
Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus …
Dose: 200 mg/kg body weight
vs.: Rotenone-PD mice without BME
Outcome: Recognition memory and AMPA receptor expression
Wirkung: None
None
Population: Rotenone-induced Parkinson's disease mouse model
Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None
vs.: None
Outcome: Cholinesterase inhibition and cognitive improvement
Wirkung: None
None
Population: In vivo animal models of AD
Other
A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via …
Dose: None
vs.: Donepezil, Estradiol
Outcome: Neurotherapeutic activity via ESR1 and ACHE
Wirkung: None
None
Population: In silico AD modeling (systems biology)
Systematic Review
n=1861
The effect of plant active substances on cognitive function in healthy older adults: a systematic …
Dose: None
vs.: Placebo or no intervention
Outcome: Cognitive function (learning, memory, executive)
Wirkung: Raisin SUCRA 95.1%; tart cherry 89.5% for memory
None
Population: Healthy older adults
Key Statistics
15
Studien
1200
Teilnehmer
↑
Positive
B
Bewertung
Referenced Papers
Frontiers in medicine
2026
JMIR research protocols
2026
Brain sciences
2025
14 Zitierungen
Inflammopharmacology
2025
4 Zitierungen
Molecular neurobiology
2025
3 Zitierungen
The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of …
Systematic Review
Frontiers in pharmacology
2025
Current Alzheimer research
2024
10 Zitierungen
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 Zitierungen
Journal of complementary …
2022
3 Zitierungen
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 Zitierungen
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
Journal of alternative …
2021
13 Zitierungen
The Senior care …
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2 Zitierungen
Alzheimer's research & …
2021
1 Zitierungen
Drug target insights
2019
103 Zitierungen
Pharmacological research
2018
67 Zitierungen
The journal of …
2017
30 Zitierungen
Medical hypotheses
2016
6 Zitierungen
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2015
82 Zitierungen
Clinical drug investigation
2014
54 Zitierungen
CNS drugs
2013
138 Zitierungen
Neurochemical research
2012
85 Zitierungen
Nutrition journal
2012
55 Zitierungen
Alternative medicine review …
1999
112 Zitierungen
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- general:
- 300-600 mg/day standardized to 50% bacosides
- memorysupport:
- 300 mg/day for minimum 8-12 weeks
Obergrenze: Not established; well-tolerated up to 600 mg/day in trials
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| 120 mL twice daily for 45 days | 6 weeks | Neutral | -- |
| 300 mg/day standardized Bacopa monnieri extract | 12 weeks | Neutral | 76 |
| 200 mg/kg body weight | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 1861 |
| None | -- | Mixed | -- |
| None | 12 weeks | Positive | -- |
Beste Einnahmezeit: With meals; effects require 8-12 weeks of consistent use
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Gastrointestinal discomfort (nausea, cramping, diarrhea)
- ⚠ Dry mouth
- ⚠ Fatigue in some individuals
- ⚠ Mild sedation at higher doses
Bekannte Wechselwirkungen
- ● Thyroid medications (may increase thyroid hormone levels)
- ● Anticholinergic drugs (opposes cholinergic enhancement)
- ● Sedative medications (additive CNS depression)
- ● Calcium channel blockers (may enhance blood pressure lowering)
Tolerierbare Höchstaufnahmemenge: Not established; well-tolerated up to 600 mg/day in trials
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Bacopa monnieri help with Age-Related Cognitive Decline?
Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Bacopa monnieri may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Bacopa monnieri should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 300-600 mg/day standardized to 50% bacosides. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bacopa monnieri?
Reported side effects may include Gastrointestinal discomfort (nausea, cramping, diarrhea), Dry mouth, Fatigue in some individuals, Mild sedation at higher doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bacopa monnieri and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
Andere Inhaltsstoffe für Age-Related Cognitive Decline
Bacopa monnieri für andere Beschwerden
References
- [1] H L N R Pradeep et al.. Front Med (Lausanne). 2026. Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in relation to constitution (Prakriti) in … doi:10.3389/fmed.2026.1702773 PubMed
- [2] Abhilasha Dwivedi et al.. JMIR Res Protoc. 2026. Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment … doi:10.2196/82891 PubMed
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- [5] Vartika Gupta et al.. Mol Neurobiol. 2025. Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus Are Associated with Recognition Memory … doi:10.1007/s12035-024-04392-1 PubMed
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- [14] Aimi Syamima Abdul Manap et al.. Drug Target Insights. 2019. Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical … doi:10.1177/1177392819866412 PubMed
- [15] Arrigo F G Cicero et al.. Pharmacol Res. 2018. Botanicals and phytochemicals active on cognitive decline: The clinical evidence. doi:10.1016/j.phrs.2017.12.029 PubMed
- [16] A F Cicero et al.. J Prev Alzheimers Dis. 2017. Short-Term Impact of a Combined Nutraceutical on Cognitive Function, Perceived Stress and Depression in Young Elderly with Cognitive Impairment: A … doi:10.14283/jpad.2016.10 PubMed
- [17] Grace M McPhee et al.. Med Hypotheses. 2016. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. doi:10.1016/j.mehy.2016.09.002 PubMed
- [18] Tamara Simpson et al.. Evid Based Complement Alternat Med. 2015. Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. doi:10.1155/2015/615384 PubMed
- [19] Ananya Sadhu et al.. Clin Drug Investig. 2014. Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product. doi:10.1007/s40261-014-0235-9 PubMed
- [20] Jerome Sarris et al.. CNS Drugs. 2013. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. doi:10.1007/s40263-013-0059-9 PubMed
- [21] Neetu Saini et al.. Neurochem Res. 2012. Neuroprotective effects of Bacopa monnieri in experimental model of dementia. doi:10.1007/s11064-012-0811-4 PubMed
- [22] Con K Stough et al.. Nutr J. 2012. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning … doi:10.1186/1475-2891-11-11 PubMed
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