Bacopa monnieri ： Age-Related Cognitive Decline
B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
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B
結論
A network meta-analysis found Bacopa outperformed Ginkgo on memory outcomes in elderly participants. Research suggests enhanced delayed word recall and improved Stroop Task performance with consistent supplementation.
Key Study Findings
Randomized Controlled Trial
6 weeks
Double-blind
Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in …
Dose: 120 mL twice daily for 45 days
vs: placebo
Outcome: telomerase activity and telomere length
効果: None
None
対象集団: elderly participants with MoCA score >=24
Randomized Controlled Trial
n=76
12 weeks
Double-blind
Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients …
Dose: 300 mg/day standardized Bacopa monnieri extract
vs: placebo
Outcome: change in composite z score of memory at …
効果: None
None
対象集団: patients with amnestic mild cognitive impairment, mean age 62.2 years, 88.3% men
Other
Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus …
Dose: 200 mg/kg body weight
vs: Rotenone-PD mice without BME
Outcome: Recognition memory and AMPA receptor expression
効果: None
None
対象集団: Rotenone-induced Parkinson's disease mouse model
Systematic Review
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.
Dose: None
vs: None
Outcome: Cholinesterase inhibition and cognitive improvement
効果: None
None
対象集団: In vivo animal models of AD
Other
A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via …
Dose: None
vs: Donepezil, Estradiol
Outcome: Neurotherapeutic activity via ESR1 and ACHE
効果: None
None
対象集団: In silico AD modeling (systems biology)
Systematic Review
n=1861
The effect of plant active substances on cognitive function in healthy older adults: a systematic …
Dose: None
vs: Placebo or no intervention
Outcome: Cognitive function (learning, memory, executive)
効果: Raisin SUCRA 95.1%; tart cherry 89.5% for memory
None
対象集団: Healthy older adults
Key Statistics
15
研究数
1200
参加者数
↑
Positive
B
グレード
Referenced Papers
Frontiers in medicine
2026
JMIR research protocols
2026
Brain sciences
2025
14 件の引用
Inflammopharmacology
2025
4 件の引用
Molecular neurobiology
2025
3 件の引用
The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of …
Systematic Review
Frontiers in pharmacology
2025
Current Alzheimer research
2024
10 件の引用
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with …
Systematic Review
Systematic reviews
2023
10 件の引用
Journal of complementary …
2022
3 件の引用
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 件の引用
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
Systematic Review
Journal of alternative …
2021
13 件の引用
The Senior care …
2021
2 件の引用
Alzheimer's research & …
2021
1 件の引用
Drug target insights
2019
103 件の引用
Pharmacological research
2018
67 件の引用
The journal of …
2017
30 件の引用
Medical hypotheses
2016
6 件の引用
Evidence-based complementary and …
2015
82 件の引用
Clinical drug investigation
2014
54 件の引用
CNS drugs
2013
138 件の引用
Neurochemical research
2012
85 件の引用
Nutrition journal
2012
55 件の引用
Alternative medicine review …
1999
112 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 300-600 mg/day standardized to 50% bacosides
- memorysupport:
- 300 mg/day for minimum 8-12 weeks
上限量： Not established; well-tolerated up to 600 mg/day in trials
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| 120 mL twice daily for 45 days | 6 weeks | Neutral | -- |
| 300 mg/day standardized Bacopa monnieri extract | 12 weeks | Neutral | 76 |
| 200 mg/kg body weight | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 1861 |
| None | -- | Mixed | -- |
| None | 12 weeks | Positive | -- |
推奨摂取タイミング： With meals; effects require 8-12 weeks of consistent use
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, cramping, diarrhea)
- ⚠ Dry mouth
- ⚠ Fatigue in some individuals
- ⚠ Mild sedation at higher doses
既知の相互作用
- ● Thyroid medications (may increase thyroid hormone levels)
- ● Anticholinergic drugs (opposes cholinergic enhancement)
- ● Sedative medications (additive CNS depression)
- ● Calcium channel blockers (may enhance blood pressure lowering)
耐容上限摂取量： Not established; well-tolerated up to 600 mg/day in trials
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Bacopa monnieri help with Age-Related Cognitive Decline?
Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Bacopa monnieri may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Bacopa monnieri should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 300-600 mg/day standardized to 50% bacosides. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Bacopa monnieri?
Reported side effects may include Gastrointestinal discomfort (nausea, cramping, diarrhea), Dry mouth, Fatigue in some individuals, Mild sedation at higher doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Bacopa monnieri and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Age-Related Cognitive Decline
Bacopa monnieri 他の症状・状態について
References
- [1] H L N R Pradeep et al.. Front Med (Lausanne). 2026. Effects of Bacopa monnieri herbal supplement on aging and neurocognitive functions, including neurophysiological assessments, in relation to constitution (Prakriti) in … doi:10.3389/fmed.2026.1702773 PubMed
- [2] Abhilasha Dwivedi et al.. JMIR Res Protoc. 2026. Efficacy of Bacopa monnieri (Linn.) on Cognitive Function and Alterations in Blood Metabolites in Patients With Amnestic Mild Cognitive Impairment … doi:10.2196/82891 PubMed
- [3] Maryam N ALNasser et al.. Brain Sci. 2025. Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review. doi:10.3390/brainsci15020215 PubMed
- [4] Mayank Roy Chowdhury et al.. Inflammopharmacology. 2025. A systems biology approach reveals dual neurotherapeutic mechanisms of Dioscorea bulbifera in Alzheimer's disease via estrogen signaling and cholinergic modulation. doi:10.1007/s10787-025-01872-1 PubMed
- [5] Vartika Gupta et al.. Mol Neurobiol. 2025. Differential Alterations in the Expression of AMPA Receptor and Its Trafficking Proteins in the Hippocampus Are Associated with Recognition Memory … doi:10.1007/s12035-024-04392-1 PubMed
- [6] Xueyan Feng et al.. Front Pharmacol. 2025. The effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of … doi:10.3389/fphar.2025.1672171 PubMed
- [7] Debasis Sen et al.. Curr Alzheimer Res. 2024. Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration. doi:10.2174/0115672050309057240404075003 PubMed
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- [11] Cindy Crawford et al.. J Altern Complement Med. 2021. Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review. doi:10.1089/acm.2021.0135 PubMed
- [12] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
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- [14] Aimi Syamima Abdul Manap et al.. Drug Target Insights. 2019. Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical … doi:10.1177/1177392819866412 PubMed
- [15] Arrigo F G Cicero et al.. Pharmacol Res. 2018. Botanicals and phytochemicals active on cognitive decline: The clinical evidence. doi:10.1016/j.phrs.2017.12.029 PubMed
- [16] A F Cicero et al.. J Prev Alzheimers Dis. 2017. Short-Term Impact of a Combined Nutraceutical on Cognitive Function, Perceived Stress and Depression in Young Elderly with Cognitive Impairment: A … doi:10.14283/jpad.2016.10 PubMed
- [17] Grace M McPhee et al.. Med Hypotheses. 2016. Cognitive training and Bacopa monnieri: Evidence for a combined intervention to alleviate age associated cognitive decline. doi:10.1016/j.mehy.2016.09.002 PubMed
- [18] Tamara Simpson et al.. Evid Based Complement Alternat Med. 2015. Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain. doi:10.1155/2015/615384 PubMed
- [19] Ananya Sadhu et al.. Clin Drug Investig. 2014. Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product. doi:10.1007/s40261-014-0235-9 PubMed
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- [21] Neetu Saini et al.. Neurochem Res. 2012. Neuroprotective effects of Bacopa monnieri in experimental model of dementia. doi:10.1007/s11064-012-0811-4 PubMed
- [22] Con K Stough et al.. Nutr J. 2012. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning … doi:10.1186/1475-2891-11-11 PubMed
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